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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
- D. Klionsky, H. Abeliovich, R. Deter
- BiologyAutophagy
- 16 February 2008
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
- Yuanyuan Tang, W. Le
- BiologyMolecular Neurobiology
- 1 March 2016
The changes of microglial phenotypes depend on the disease stages and severity; mastering the stage-specific switching of M1/M2 phenotypes within appropriate time windows may provide better therapeutic benefit.
Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
- Xiao-jie Zhang, Liang Li, W. Le
- BiologyAutophagy
- 1 April 2011
The findings suggest that selective degeneration of MNs is associated with the impairment of the autophagy pathway and that rapamycin treatment may exacerbate the pathological processing through apoptosis and other mechanisms in the ALS mice.
Genetics of amyotrophic lateral sclerosis: an update
- Sheng Chen, P. Sayana, Xiao-jie Zhang, W. Le
- BiologyMolecular Neurodegeneration
- 13 August 2013
This review is to update the recent discoveries in genetics of ALS, which may provide insight information to help us better understanding of the disease neuropathogenesis.
Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson's Disease
- Yuncheng Wu, Xinqun Li, T. Pan
- Biology, ChemistryNeurosignals
- 22 July 2011
Results showed that resveratrol protected against rotenone-induced apoptosis in SH-SY5Y cells and enhanced degradation of α-synucleins in α- synuclein-expressing PC12 cell lines via autophagy induction, suggesting that AMPK-SIRT1-autophagy pathway plays an important role in the neuroprotection by resver atrol on PD cellular models.
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.
- T. Pan, S. Kondo, W. Le, J. Jankovic
- BiologyBrain : a journal of neurology
- 1 August 2008
The demonstration that alpha-synuclein is degraded by both proteasome and autophagy indicates a possible linkage between the dysfunction of the UPS or ALP and the occurrence of Parkinson's disease.
Pitx3 Is a Critical Mediator of GDNF-Induced BDNF Expression in Nigrostriatal Dopaminergic Neurons
- Changgeng Peng, Liviu Aron, W. Le
- BiologyThe Journal of Neuroscience
- 7 September 2011
It is shown that a transient expression of glial cell line-derived neurotrophic factor (GDNF) in the murine ventral midbrain (VM) induces transcription of Pitx3 via NF-κB-mediated signaling, and thatpitx3 is in turn required for activating the expression of brain- derived neurotrophic factors (BDNF) on a rostrolateral mdDA neuron subpopulation during embryogenesis.
Redox control of the survival of healthy and diseased cells.
- Yuxing Zhang, Yanzhi Du, W. Le, Kankan Wang, N. Kieffer, Ji Zhang
- BiologyAntioxidants and Redox Signaling
- 12 October 2011
Due to the complexity of ROS and their cellular impacts, it is believed that the goal to design more effective approaches or agents may require a better understanding of mechanisms of ROS production, particularly their multifaceted impacts in disease at biochemical, molecular, genetic, and epigenetic levels.
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