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Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
  • Y. Tang, W. Le
  • Biology, Medicine
  • Molecular Neurobiology
  • 1 March 2016
One of the most striking hallmarks shared by various neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease (AD), and amyotrophic lateral sclerosis, is microglia-mediatedExpand
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Genetics of amyotrophic lateral sclerosis: an update
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has been done in the past fewExpand
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Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but the detailed mechanisms are largely unknown. Our previous study has shown that autophagy isExpand
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The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.
The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) are the two most important mechanisms that normally repair or remove abnormal proteins. Alterations in the function of theseExpand
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Pitx3 Is a Critical Mediator of GDNF-Induced BDNF Expression in Nigrostriatal Dopaminergic Neurons
Pitx3 is a critical homeodomain transcription factor for the proper development and survival of mesodiencephalic dopaminergic (mdDA) neurons in mammals. Several variants of this gene have beenExpand
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Pathological role of hypoxia in Alzheimer's disease
  • X. Zhang, W. Le
  • Biology, Medicine
  • Experimental Neurology
  • 1 June 2010
The majority cases of Alzheimer's disease (AD) are sporadic late-onset form not being linked to APP and PS1 gene mutations. It is believed that the environmental risk factors play an important roleExpand
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Redox control of the survival of healthy and diseased cells.
Abstract Cellular redox homeostasis is the first line of defense against diverse stimuli and is crucial for various biological processes. Reactive oxygen species (ROS), byproducts of numerousExpand
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Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease
J. Neurochem. (2010) 115, 188–199.
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Altered macroautophagy in the spinal cord of SOD1 mutant mice
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by selective loss of motor neurons (MNs). About 20% familial cases of ALS (fALS) carried the Cu, Zn-superoxide dismutaseExpand
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Spinal cord dopamine receptor expression and function in mice with 6‐OHDA lesion of the A11 nucleus and dietary iron deprivation
It is suggested that dysfunction of the diencephalospinal dopaminergic (DAergic) pathway may cause restless legs syndrome. We examined the mRNA and protein levels as well as DA receptor subtypesExpand
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