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- Publications
- Influence
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
One of the most striking hallmarks shared by various neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease (AD), and amyotrophic lateral sclerosis, is microglia-mediated… Expand
Genetics of amyotrophic lateral sclerosis: an update
- S. Chen, P. Sayana, Xiaojie Zhang, W. Le
- Biology, Medicine
- Molecular Neurodegeneration
- 13 August 2013
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving both upper motor neurons (UMN) and lower motor neurons (LMN). Enormous research has been done in the past few… Expand
Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
- Xiaojie Zhang, L. Li, +5 authors W. Le
- Biology, Medicine
- Autophagy
- 1 April 2011
Aberrant protein misfolding may contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS) but the detailed mechanisms are largely unknown. Our previous study has shown that autophagy is… Expand
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.
- T. Pan, S. Kondo, W. Le, J. Jankovic
- Biology, Medicine
- Brain : a journal of neurology
- 1 August 2008
The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway (ALP) are the two most important mechanisms that normally repair or remove abnormal proteins. Alterations in the function of these… Expand
Pitx3 Is a Critical Mediator of GDNF-Induced BDNF Expression in Nigrostriatal Dopaminergic Neurons
- Changgeng Peng, L. Aron, +4 authors W. Le
- Biology, Medicine
- The Journal of Neuroscience
- 7 September 2011
Pitx3 is a critical homeodomain transcription factor for the proper development and survival of mesodiencephalic dopaminergic (mdDA) neurons in mammals. Several variants of this gene have been… Expand
Pathological role of hypoxia in Alzheimer's disease
The majority cases of Alzheimer's disease (AD) are sporadic late-onset form not being linked to APP and PS1 gene mutations. It is believed that the environmental risk factors play an important role… Expand
Redox control of the survival of healthy and diseased cells.
- Y. Zhang, Y. Du, W. Le, K. Wang, Nelly Kieffer, J. Zhang
- Biology, Medicine
- Antioxidants & redox signaling
- 12 October 2011
Abstract Cellular redox homeostasis is the first line of defense against diverse stimuli and is crucial for various biological processes. Reactive oxygen species (ROS), byproducts of numerous… Expand
Proteasome inhibition modeling nigral neuron degeneration in Parkinson’s disease
- W. Xie, X. Li, C. Li, Wen Zhu, J. Jankovic, W. Le
- Biology, Medicine
- Journal of neurochemistry
- 1 October 2010
J. Neurochem. (2010) 115, 188–199.
Altered macroautophagy in the spinal cord of SOD1 mutant mice
- L. Li, Xiaojie Zhang, W. Le
- Biology, Medicine
- Autophagy
- 21 January 2008
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by selective loss of motor neurons (MNs). About 20% familial cases of ALS (fALS) carried the Cu, Zn-superoxide dismutase… Expand
Spinal cord dopamine receptor expression and function in mice with 6‐OHDA lesion of the A11 nucleus and dietary iron deprivation
- Hongru Zhao, Wen Zhu, +4 authors W. Le
- Chemistry, Medicine
- Journal of neuroscience research
- 1 April 2007
It is suggested that dysfunction of the diencephalospinal dopaminergic (DAergic) pathway may cause restless legs syndrome. We examined the mRNA and protein levels as well as DA receptor subtypes… Expand