tyrosinyl-5'-AMP

Site-directed mutagenesis of the tyrosyl-tRNA synthetase followed by kinetic studies has shown that residues which are distant… Expand

The activity of mutant enzymes can be analyzed quantitatively by structure-activity relationships in a manner analogous to Br… Expand

The recognition of transfer-RNA by their cognate aminoacyl-tRNA synthetases is the crucial step in the translation of the genetic… Expand

Protein engineering is being used increasingly to study the fine details of the structure and activity of enzymes. How can small… Expand

The principal catalytic factor in the activation of tyrosine by the tyrosyl-tRNA synthetase is found to be improved binding of… Expand

Abstract Tyrosyl-tRNA synthetase from Bacillus stearothermophilus is a dimeric molecule of approximately 90,000 M r . The crystal… Expand

The following observations show that the formation of isoleucyl-tRNA catalyzed by the isoleucyl-tRNA synthetase from Escherichia… Expand

A rapid mixing and quenching device is described which operates efficiently in the range of 150 msec to several minutes as well… Expand

The tyrosyl-tRNA synthetase from Escherichia coli binds only 1 mol of tRNA, tyrosine, and tyrosyl adenylate per mol of enzyme… Expand

The interaction of the tyrosyl-tRNA synthetase from Bacillus stearothermophilus with its substrates in the aminoacyl adenylation… Expand