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tyrosine-arginine ligase activity
Known as:
tyrosyl-arginine synthase activity
, kyotorphin synthase activity
, kyotorphin-synthesizing enzyme activity
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Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+). [EC:6.3.2.24, RHEA:15348]
National Institutes of Health
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Review
2011
Review
2011
The unique brain dipeptide kyotorphin ... Review
E. Dzambazova
,
A. Bocheva
2011
Corpus ID: 14355746
Endogenous opioid peptides take part in various functions as hormones or neuromodulators. In 1979, Takagi and his co-workers…
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2010
2010
Eryngase: a Pleurotus eryngii aminopeptidase exhibiting peptide bond formation activity
J. Arima
,
M. Chiba
,
Tsuyoshi Ichiyanagi
,
Y. Yabuta
,
N. Mori
,
T. Aimi
Applied Microbiology and Biotechnology
2010
Corpus ID: 22495243
An aminopeptidase that has peptide bond formation activity was identified in the cell-free extract of carpophore of Pleurotus…
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2010
2010
THE UNIQUE BRAIN DIPEPTIDE KYOTORPHIN - FROM DISCOVERY TO NOWADAYS
E. Dzambazova
,
A. Bocheva
2010
Corpus ID: 97193921
1999
1999
Effect of L-arginine in central spinal pain syndrome
E. I. Danilova
,
V. N. Grafova
,
M. Kukushkin
,
V. A. Zinkevich
Bulletin of experimental biology and medicine
1999
Corpus ID: 22304594
When applied in combination with penicillin (2000 U) to the dorsal surface of the spinal cord, L-arginine in a low concentration…
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1994
1994
The intestinal uptake of "enzymatically-stable" peptide drugs in rats as influenced by D-glucose in situ.
Z. Hu
,
E. Tse
,
D. Monkhouse
,
C. Oh
,
D. Fleisher
Life Science
1994
Corpus ID: 37232269
1990
1990
The analgesic activity of some kyotorphin-tuftsin analogs.
I. Siemion
,
A. Kubik
,
E. Nawrocka
,
E. Obuchowicz
,
K. Gołba
,
Z. Herman
Polish journal of pharmacology and pharmacy
1990
Corpus ID: 43448225
The analgesic potency of the C-terminal dipeptide of tuftsin (Pro-Arg) was found to be much stronger than that of the C-terminal…
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1986
1986
A putative met-enkephalin releaser, kyotorphin enhances intracellular Ca2+ in the synaptosomes.
H. Ueda
,
Y. Yoshihara
,
H. Takagi
Biochemical and Biophysical Research…
1986
Corpus ID: 9587771
1981
1981
Isolation and identification of an analgesic opioid dipeptide kyotorphin (TYR-ARG) from bovine brain
H. Shiomi
,
H. Ueda
,
H. Takagi
Neuropharmacology
1981
Corpus ID: 21125097
Highly Cited
1980
Highly Cited
1980
Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord
H. Ueda
,
H. Shiomi
,
H. Takagi
Brain Research
1980
Corpus ID: 22265872
1980
1980
Studies on peptides. XCIV. Synthesis and activity of kyotorphin and its analogs.
H. Yajima
,
H. Ogawa
,
H. Ueda
,
H. Takagi
Chemical and pharmaceutical bulletin
1980
Corpus ID: 46147564
A dipeptide named kyotorphin, H-Tyr-Arg-OH, and its retro isomer were synthesized using NG-mesitylene-2-sulfonylarginine. Two…
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