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tyrosine-arginine ligase activity

Known as: tyrosyl-arginine synthase activity, kyotorphin synthase activity, kyotorphin-synthesizing enzyme activity 
Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+). [EC:6.3.2.24, RHEA:15348]
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Endogenous opioid peptides take part in various functions as hormones or neuromodulators. In 1979, Takagi and his co-workers… 
2010
2010
An aminopeptidase that has peptide bond formation activity was identified in the cell-free extract of carpophore of Pleurotus… 
1999
1999
When applied in combination with penicillin (2000 U) to the dorsal surface of the spinal cord, L-arginine in a low concentration… 
1990
1990
The analgesic potency of the C-terminal dipeptide of tuftsin (Pro-Arg) was found to be much stronger than that of the C-terminal… 
1980
1980
A dipeptide named kyotorphin, H-Tyr-Arg-OH, and its retro isomer were synthesized using NG-mesitylene-2-sulfonylarginine. Two…