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tyrosine-arginine ligase activity

Known as: tyrosyl-arginine synthase activity, kyotorphin synthase activity, kyotorphin-synthesizing enzyme activity 
Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+). [EC:6.3.2.24, RHEA:15348]
National Institutes of Health

Papers overview

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Review
2011
Review
2011
The unique brain dipeptide kyotorphin ... Review
Endogenous opioid peptides take part in various functions as hormones or neuromodulators. In 1979, Takagi and his co-workers… 
2010
2010
Eryngase: a Pleurotus eryngii aminopeptidase exhibiting peptide bond formation activity
An aminopeptidase that has peptide bond formation activity was identified in the cell-free extract of carpophore of Pleurotus… 
2010
2010
THE UNIQUE BRAIN DIPEPTIDE KYOTORPHIN - FROM DISCOVERY TO NOWADAYS
1999
1999
Effect of L-arginine in central spinal pain syndrome
When applied in combination with penicillin (2000 U) to the dorsal surface of the spinal cord, L-arginine in a low concentration… 
1994
1994
The intestinal uptake of "enzymatically-stable" peptide drugs in rats as influenced by D-glucose in situ.
1990
1990
The analgesic activity of some kyotorphin-tuftsin analogs.
The analgesic potency of the C-terminal dipeptide of tuftsin (Pro-Arg) was found to be much stronger than that of the C-terminal… 
1986
1986
A putative met-enkephalin releaser, kyotorphin enhances intracellular Ca2+ in the synaptosomes.
1981
1981
Isolation and identification of an analgesic opioid dipeptide kyotorphin (TYR-ARG) from bovine brain
Highly Cited
1980
Highly Cited
1980
Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord
1980
1980
Studies on peptides. XCIV. Synthesis and activity of kyotorphin and its analogs.
A dipeptide named kyotorphin, H-Tyr-Arg-OH, and its retro isomer were synthesized using NG-mesitylene-2-sulfonylarginine. Two… 
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