FAQ

tyrosine-arginine ligase activity

Known as: tyrosyl-arginine synthase activity, kyotorphin synthase activity, kyotorphin-synthesizing enzyme activity 
Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+). [EC:6.3.2.24, RHEA:15348]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2016
01219802016

Papers overview

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2016
2016
Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules.
Mitochondrial oxidative damage contributes to a wide range of pathologies, including ischemia/reperfusion (I/R) injury… (More)
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2015
2015
Correlation between membrane translocation and analgesic efficacy in kyotorphin derivatives.
Amidated kyotorphin (L-Tyr-L-Arg-NH2; KTP-NH2) causes analgesia when systemically administered. The lipophilic ibuprofen… (More)
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2014
2014
Kyotorphin analogues containing unnatural amino acids: synthesis, analgesic activity and computer modeling of their interactions with μ-receptor
Kyotorphin (KTP; Tyr-Arg) an endogenous neuropeptide is potently analgesic when delivered directly to CNS. An effort to enhance… (More)
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2008
2008
Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2.
We have recently identified a Na+/Cl--coupled transport system in mammalian cells for endogenous and synthetic opioid peptides… (More)
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2007
2007
The pH-dependent conformational states of kyotorphin: a constant-pH molecular dynamics study.
An extensive conformational study of the analgesic dipeptide kyotorphin (L-Tyr-L-Arg) at different pH values was performed using… (More)
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2006
2006
Conformational and orientational guidance of the analgesic dipeptide kyotorphin induced by lipidic membranes: putative correlation toward receptor docking.
The analgesic dipeptide kyotorphin (L-Tyr-L-Arg) and an acylated kyotorphin derivative were studied by a combination of… (More)
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1997
1997
Preference of Peyer's patches to jejunal epithelium for intestinal absorption of oligopeptides, tyrosylglycylglycine and D-kyotorphin.
The intestinal absorption of oligopeptides, peptidase-degradable tyrosylglycylglycine (TGG) and peptidase-resistant L-tyrosyl-D… (More)
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1994
1994
Transport of Low and High Molecular Peptides Across Rabbit Peyer's Patches
The permeability of peptides across rabbit jejunal epithelium (JE) and Peyer’s patches (PP) was compared. Kyotorphin (L-tyrosyl-L… (More)
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1981
1981
Isolation and identification of an analgesic opioid dipeptide kyotorphin (Tyr-Arg) from bovine brain.
 
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1980
1980
Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord.
Using high performance liquid chromatography, we measured kyotorphin content in discrete regions of the rat brain and spinal cord… (More)
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