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TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade
It is demonstrated that TRPM1-L is a component of the ON BC transduction channel downstream of mGluR6 in ON BCs, and functions as a constitutively active nonselective cation channel and its activity is negatively regulated by Go in the mGLUR6 cascade. Expand
Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms.
  • H. Ueda
  • Medicine, Biology
  • Pharmacology & therapeutics
  • 2006
The current study using lysophosphatidic acid (LPA) receptor knockout mice revealed that LPA produced by nerve injury initiates neuropathic pain and demyelination following partial sciatic nerve ligation (PSNL). Expand
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
Intrathecal injection of LPA induced behavioral, morphological and biochemical changes similar to those observed after nerve ligation, which imply that receptor-mediated LPA signaling is crucial in the initiation of neuropathic pain. Expand
Enhanced Spinal Nociceptin Receptor Expression Develops Morphine Tolerance and Dependence
It is suggested that the spinal NOR system develops anti-opioid plasticity observed on morphine tolerance and dependence, as well as a parallel enhancement of NOR gene expression only in the spinal cord during chronic morphine treatments. Expand
Loss of Peripheral Morphine Analgesia Contributes to the Reduced Effectiveness of Systemic Morphine in Neuropathic Pain
The data suggest that the lower potency of systemic morphine in neuropathic pain could be at least partly caused by the decreased MOP expression in DRG and subsequent loss of peripheral morphine analgesia in such a condition. Expand
Increased Expression of Vanilloid Receptor 1 on Myelinated Primary Afferent Neurons Contributes to the Antihyperalgesic Effect of Capsaicin Cream in Diabetic Neuropathic Pain in Mice
It is reported that an up-regulation of VR1 expression on myelinated fibers contributes to the antihyperalgesic effect of capsaicin cream in streptozotocin (STZ)-induced diabetic neuropathic pain. Expand
Protein kinase C involvement in homologous desensitization of delta- opioid receptor coupled to Gi1-phospholipase C activation in Xenopus oocytes
Results suggest that protein kinase C is involved in the homologous desensitization of delta-opioid receptors. Expand
TRPM1: a vertebrate TRP channel responsible for retinal ON bipolar function.
This review covers the significant discoveries on the physiological function and regulatory mechanism of the TRPM1 channel in retinal ON bipolar cells and the association of human TR PM1 mutations with congenital stationary night blindness. Expand
Epigenetic Gene Silencing Underlies C-Fiber Dysfunctions in Neuropathic Pain
It is found that nerve injury upregulates neuron-restrictive silencer factor expression in the DRG neurons mediated through epigenetic mechanisms, and data suggest that NRSF causes pathological and pharmacological dysfunction of C-fibers, which underlies the negative symptoms in neuropathic pain. Expand
Inhibitory effects of sesquiterpenes from bay leaf on nitric oxide production in lipopolysaccharide-activated macrophages: structure requirement and role of heat shock protein induction.
The results suggested that, as one of their mechanisms of action, sesquiterpene lactones induce HSP 72 thereby preventing nuclear factor-kappaB activation followed by iNOS induction in accordance with induction of heat shock protein 72 (HSP 72). Expand