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TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade
An essential step in intricate visual processing is the segregation of visual signals into ON and OFF pathways by retinal bipolar cells (BCs). Glutamate released from photoreceptors modulates theExpand
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Design of the linkers which effectively separate domains of a bifunctional fusion protein.
With the aim of separating the domains of a bifunctional fusion protein, the ability of several lengths of helix-forming peptides to separate two weakly interacting beta-can domains was compared withExpand
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Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms.
  • H. Ueda
  • Biology, Medicine
  • Pharmacology & therapeutics
  • 2006
Many known painkillers are not always effective in the therapy of chronic neuropathic pain manifested by hyperalgesia and tactile allodynia. The mechanisms underlying neuropathic pain appear to beExpand
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Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the development ofExpand
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Underwater observations on copepod swarms in temperate and subtropical waters
Swarms of 8 copepod species were visually observed in temperate and subtropical waters along the coast of Japan from 1975 to 1981. Irregular ball-shaped swarms, with diameters less than 1 m. wereExpand
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Enhanced Spinal Nociceptin Receptor Expression Develops Morphine Tolerance and Dependence
The tolerance and dependence after chronic medication with morphine are thought to be representative models for studying the plasticity, including the remodeling of neuronal networks. To test theExpand
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Loss of Peripheral Morphine Analgesia Contributes to the Reduced Effectiveness of Systemic Morphine in Neuropathic Pain
It is well known that the analgesic potency of morphine is reduced in neuropathic pain. In this study, we demonstrate that the decreased effectiveness of systemic morphine in neuropathic pain mightExpand
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Epigenetic Gene Silencing Underlies C-Fiber Dysfunctions in Neuropathic Pain
Peripheral nerve injury causes neuropathic pain, which is characterized by the paradoxical sensations of positive and negative symptoms. Clinically, negative signs are frequently observed; however,Expand
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Increased Expression of Vanilloid Receptor 1 on Myelinated Primary Afferent Neurons Contributes to the Antihyperalgesic Effect of Capsaicin Cream in Diabetic Neuropathic Pain in Mice
Topical capsaicin is believed to alleviate pain by desensitizing the vanilloid receptor 1 (VR1) at the peripheral nerve endings. Here, we report that an up-regulation of VR1 expression on myelinatedExpand
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