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tryprostatin B

 
National Institutes of Health

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Related topics

2 relations

Broader (2)

Indole AlkaloidsPiperazines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Total Synthesis of Tryprostatin B: Synthesis and Asymmetric Phase-Transfer-Catalyzed Reaction of Prenylated Gramine Salt.
A concise and efficient total synthesis of microtubule inhibitor tryprostatin B (1) is described. The key step is the preparation… Expand
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2018
2018
A Nonheme FeII/2-Oxoglutarate-Dependent Oxygenase Catalyzes a Double Bond Migration within a Dimethylallyl Moiety Accompanied by Hydroxylation.
Prenylation of cyclodipeptides contributes largely to the structure diversification and biological activity. The prenylated… Expand
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2017
2017
Mechanism of Formation of the Nonstandard Product in the Prenyltransferase Reaction of the G115T Mutant of FtmPT1: A Case of Reaction Dynamics Calling the Shots?
FtmPT1 is a fungal indole prenyltransferase that affords Tryprostatin B from Brevianamide F and dimethylallyl pyrophosphate… Expand
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2015
2015
Computational design of Tryprostatin-A derivatives as novel αβ-tubulin inhibitors.
In the first part of this work, binding energies, inhibition constants and binding modes for a group of previously synthesized… Expand
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2009
2009
Improved tryprostatin B production by heterologous gene expression in Aspergillus nidulans.
Tryprostatin B, a prenylated diketopiperazine with anti-tubulin activity, has been overproduced in fungal culture by expression… Expand
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2003
2003
Brief total synthesis of the cell cycle inhibitor tryprostatin B and related preparation of its alanine analogue.
Tryprostatin B was synthesized in 32% overall yield from the readily available dipeptide anhydride cyclo-(l-Trp-l-Pro). Its… Expand
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2000
2000
Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.
Tryprostatin B and demethoxyfumitremorgin C are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. N… Expand
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