tryprostatin B
National Institutes of Health
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Prenylation of cyclodipeptides contributes largely to the structure diversification and biological activity. The prenylated…
FtmPT1 is a fungal indole prenyltransferase that affords Tryprostatin B from Brevianamide F and dimethylallyl pyrophosphate…
In the first part of this work, binding energies, inhibition constants and binding modes for a group of previously synthesized…
Tryprostatin B was synthesized in 32% overall yield from the readily available dipeptide anhydride cyclo-(l-Trp-l-Pro). Its…