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tryprostatin B

 
National Institutes of Health

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2019
2019
A concise and efficient total synthesis of microtubule inhibitor tryprostatin B (1) is described. The key step is the preparation… Expand
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2018
2018
Prenylation of cyclodipeptides contributes largely to the structure diversification and biological activity. The prenylated… Expand
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2017
2017
FtmPT1 is a fungal indole prenyltransferase that affords Tryprostatin B from Brevianamide F and dimethylallyl pyrophosphate… Expand
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2015
2015
In the first part of this work, binding energies, inhibition constants and binding modes for a group of previously synthesized… Expand
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2009
2009
Tryprostatin B, a prenylated diketopiperazine with anti-tubulin activity, has been overproduced in fungal culture by expression… Expand
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2003
2003
Tryprostatin B was synthesized in 32% overall yield from the readily available dipeptide anhydride cyclo-(l-Trp-l-Pro). Its… Expand
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2000
2000
Tryprostatin B and demethoxyfumitremorgin C are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. N… Expand
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