tryprostatin B

A concise and efficient total synthesis of microtubule inhibitor tryprostatin B (1) is described. The key step is the preparation… Expand

Prenylation of cyclodipeptides contributes largely to the structure diversification and biological activity. The prenylated… Expand

FtmPT1 is a fungal indole prenyltransferase that affords Tryprostatin B from Brevianamide F and dimethylallyl pyrophosphate… Expand

In the first part of this work, binding energies, inhibition constants and binding modes for a group of previously synthesized… Expand

Tryprostatin B, a prenylated diketopiperazine with anti-tubulin activity, has been overproduced in fungal culture by expression… Expand

Tryprostatin B was synthesized in 32% overall yield from the readily available dipeptide anhydride cyclo-(l-Trp-l-Pro). Its… Expand

Tryprostatin B and demethoxyfumitremorgin C are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. N… Expand