FAQ

transforming growth factor beta activation

Known as: TGF-beta activation, latent TGF-beta activation, L-TGF-beta activation 
The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
0102019882017

Related topics

Related topics

3 relations
negative regulation of transforming growth factor beta activationregulation of transforming growth factor beta activation

Broader (1)

transforming growth factor beta production

Related mentions per year

Related mentions per year

1986-2017
19801990200020102020
transforming growth factor beta activation
transforming growth factor beta production
negative regulation of transforming growth factor beta activation
regulation of transforming growth factor beta activation

Papers overview

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Highly Cited
2008
Highly Cited
2008
Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.
RATIONALE In experimental models, lung fibrosis is dependent on transforming growth factor (TGF)-beta signaling. TGF-beta is… (More)
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Highly Cited
2007
Highly Cited
2007
Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition.
Transforming growth factor beta1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to… (More)
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Highly Cited
2003
Highly Cited
2003
Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome.
Marfan syndrome is an autosomal dominant disorder of connective tissue caused by mutations in fibrillin-1 (encoded by FBN1 in… (More)
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Highly Cited
2003
Highly Cited
2003
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.
Integrins are heterodimeric cell-surface proteins that regulate cell growth, migration and survival. We have shown previously… (More)
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Highly Cited
2003
Highly Cited
2003
Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation.
During blood vessel assembly, endothelial cells recruit mesenchymal progenitors and induce their differentiation into mural cells… (More)
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Highly Cited
2000
Highly Cited
2000
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.
We have uncovered a novel functional relationship between the hyaluronan receptor CD44, the matrix metalloproteinase-9 (MMP-9… (More)
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Highly Cited
1999
Highly Cited
1999
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP.
Connective tissue growth factor (CTGF) is a cysteine-rich peptide synthesized and secreted by fibroblastic cells after activation… (More)
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Highly Cited
1999
Highly Cited
1999
The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta.
One of the primary points of regulation of transforming growth factor-beta (TGF-beta) activity is control of its conversion from… (More)
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Highly Cited
1995
Highly Cited
1995
Regulation of transforming growth factor-beta activation by discrete sequences of thrombospondin 1.
Transforming growth factor-beta (TGF-beta) is a potent growth regulatory protein secreted by virtually all cells in a latent form… (More)
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Highly Cited
1994
Highly Cited
1994
Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta.
Previous investigations have demonstrated that growing mesangial cells in high glucose concentration stimulates extracellular… (More)
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