transforming growth factor beta activation

Known as: TGF-beta activation, latent TGF-beta activation, L-TGF-beta activation 
The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
0102019882017

Papers overview

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Highly Cited
2008
Highly Cited
2008
RATIONALE In experimental models, lung fibrosis is dependent on transforming growth factor (TGF)-beta signaling. TGF-beta is… (More)
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Highly Cited
2007
Highly Cited
2007
Transforming growth factor beta1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis, but it can switch to… (More)
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Highly Cited
2003
Highly Cited
2003
Marfan syndrome is an autosomal dominant disorder of connective tissue caused by mutations in fibrillin-1 (encoded by FBN1 in… (More)
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Highly Cited
2003
Highly Cited
2003
Integrins are heterodimeric cell-surface proteins that regulate cell growth, migration and survival. We have shown previously… (More)
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Highly Cited
2003
Highly Cited
2003
During blood vessel assembly, endothelial cells recruit mesenchymal progenitors and induce their differentiation into mural cells… (More)
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Highly Cited
2000
Highly Cited
2000
We have uncovered a novel functional relationship between the hyaluronan receptor CD44, the matrix metalloproteinase-9 (MMP-9… (More)
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Highly Cited
1999
Highly Cited
1999
Connective tissue growth factor (CTGF) is a cysteine-rich peptide synthesized and secreted by fibroblastic cells after activation… (More)
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Highly Cited
1999
Highly Cited
1999
One of the primary points of regulation of transforming growth factor-beta (TGF-beta) activity is control of its conversion from… (More)
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Highly Cited
1995
Highly Cited
1995
Transforming growth factor-beta (TGF-beta) is a potent growth regulatory protein secreted by virtually all cells in a latent form… (More)
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Highly Cited
1994
Highly Cited
1994
Previous investigations have demonstrated that growing mesangial cells in high glucose concentration stimulates extracellular… (More)
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