negative regulation of transforming growth factor beta activation

Known as: inhibition of L-TGF-beta activation, down-regulation of transforming growth factor beta activation, inhibition of latent TGF-beta activation 
Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor beta activation. [GOC:sl, GOC:TermGenie]
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

biological control
transforming growth factor beta activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3.
Members of the Snail family of transcription factors have been shown to induce epithelial-mesenchymal transition (EMT), a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2004
Review
2004
Mammalian transforming growth factor-betas: Smad signaling and physio-pathological roles.
Since its discovery in the early 1980s, transforming growth factor-beta (TGF-beta) has emerged as a family of growth factors… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.
Transforming growth factor beta (TGF-beta), a pleiotropic cytokine that regulates cell growth and differentiation, is secreted by… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells.
In this study we have examined the interaction between CD44 (a hyaluronan (HA) receptor) and the transforming growth factor beta… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Preoperative plasma levels of transforming growth factor beta(1) (TGF-beta(1)) strongly predict progression in patients undergoing radical prostatectomy.
PURPOSE Elevated local and circulating levels of transforming growth factor beta(1) (TGF-beta(1)) have been associated with… (More)
Is this relevant?
Review
2000
Review
2000
Transforming growth factor-beta: pleiotropic role in the regulation of hematopoiesis.
Hematopoiesis is a remarkable cell-renewal process that leads to the continuous generation of large numbers of multiple mature… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
Transforming growth factor beta (TGF beta) family members are secreted in inactive complexes with a latency-associated peptide… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The activation sequence of thrombospondin-1 interacts with the latency-associated peptide to regulate activation of latent transforming growth factor-beta.
One of the primary points of regulation of transforming growth factor-beta (TGF-beta) activity is control of its conversion from… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.
Smad proteins play a key role in the intracellular signalling of transforming growth factor beta (TGF beta), which elicits a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis.
TGF-beta signaling is mediated through two types of serine/threonin kinase-containing receptors, type I (TGF-betaRI) and type II… (More)
Is this relevant?