tozadenant
National Institutes of Health
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Adenosine is a neuromodulator that regulates the body’s response to dopamine and another neurotransmitter in the brain that is…
Objective: To characterize the TOZ-PD study population. Background: Many patients with Parkinson’s disease (PD) continue to…
Objective Investigate a combination of two clinically tested drugs, the NR2B antagonist Radiprodil and the A2A antagonist…
Abstract 1. This phase-I study (NCT02240290) was designed to investigate the human absorption, disposition and mass balance of…
Treatment of motor fluctuations in Parkinson's disease (PD) remains an unmet challenge. Adenosine 2A (A2A) receptors are located…
A carefully controlled study allowed us to compare the sensitivity of ASL (arterial spin labeling) and BOLD (blood oxygen level…
Introduction: Adenosine A2A receptors are localized in the brain, mainly within the caudate and putamen nuclei of the basal…
In Parkinson's disease, the long-term use of dopamine replacing agents is associated with the development of motor complications…
A carefully controlled study allowed us to compare the sensitivity of ASL (arterial spin labeling) and BOLD (blood oxygen level…