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Medicinal Plants Database and Three Dimensional Structure of the Chemical Compounds from Medicinal Plants in Indonesia
During this era of new drug designing, medicinal plants had become a very interesting object of further research. Pharmacology screening of active compound of medicinal plants would be time consumingExpand
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In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database
TLDR
Sirtuin 1 (SIRT1) is a class III family of protein histone deacetylases involved in NAD+-dependent reactions. Expand
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In silico Activity Analysis of Saponins and 2, 5-Piperazinedione from Marine Organism against Murine Double Minute-2 Inhibitor and Procaspase-3 Activator
Objective: Cancer is a disease that can occur because of apoptosis failure. One of the causes of apoptosis failure is the presence of MDM2 inhibiting the activity of p53 so procaspase-3 could not beExpand
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In Silico Approach to Finding New Active Compounds from Histone Deacetylase (HDAC) Family.
BACKGROUND Histone Deacetylase (HDAC) enzymes in the human body play an important role in the transcriptional regulation of gene expression. In the last decade, HDAC inhibitors and activators haveExpand
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Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor
HIV-1 (Human immunodeficiency virus type 1) is a member of retrovirus family that could infect human and causing AIDS disease. AIDS epidemic is one of most destructive diseases in modern era. ThereExpand
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Virtual Screening of Indonesian Herbal Database as HIV-1 Protease Inhibitor
HIV-1 (Human immunodeficiency virus type 1)׳s infection is considered as one of most harmful disease known by human, the survivability rate of the host reduced significantly when it developed intoExpand
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Synthesis of Polymer-Drug Conjugates Using Natural Polymer: What, Why and How?
For years, natural polymers have played a significant role in pharmaceutical field due to their biocompatibility and biodegradability. In Indonesia, most research in natural polymers focus onExpand
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Sera Anti-P53 Antibody Provides New Information Which Explains the Link Between Diabetes and Cancer
Introduction Abnormalities in glucose metabolism in diabetic patients may lead to an increased risk of certain cancers. Epidemiological studies and meta-analysis have shown that factors such asExpand
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Optimization of Microwave-Assisted Extraction of Active Compounds, Antioxidant Activity and Angiotensin Converting Enzyme (ACE) Inhibitory Activity from Peperomia pellucida (L.) Kunth
Introduction: to obtain the optimum extraction conditions of total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity (AA) and angiotensin converting enzyme (ACE) inhibitoryExpand
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EFFICACY OF IONIC LIQUID [MIM]BR-BASED MAE ON RESVERATROL AND PHENOLIC COMPOUNDS EXTRACTION FROM GNETUM GNEMON SEEDS AND THEIR DPP-4 INHIBITORY ACTIVITY
Objective : This study aimed to determine the inhibitory activity of 1-butyl-3-methylimidazolium bromide ([bmim]Br) extracts of melinjo seeds (Gnetum gnemon) on dipeptidyl peptidase-4 (DPP-4).Expand