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Quantification of indirect pathway inhibition by the adenosine A 2a antagonist SYN115 in Parkinson disease. Adenosine A 2a… Expand BACKGROUND
Many patients with Parkinson's disease have motor fluctuations despite treatment with available drugs. Tozadenant… Expand Parkinson's disease (PD) is a chronic, progressive disease of the central nervous system (CNS), characterized by a slow loss of… Expand A(2A) receptor antagonists have been proposed as therapeutic tools for dopaminergically-relevant diseases, including Parkinson's… Expand Background: Positron Emission Tomography imaging studies provide evidence of reduced dopamine function in cocaine dependent… Expand ABSTRACT Our current wish list for the treatment of Parkinson's disease (PD) includes therapies that will provide robust and… Expand Adenosine A2a receptor antagonists reduce symptom severity in Parkinson disease (PD) and animal models. Rodent studies support… Expand