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torsemide
Known as:
1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea
, Torasemidum
, 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea
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An anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop…
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National Institutes of Health
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Related topics
Related topics
23 relations
Broader (4)
Antihypertensive Agents
Diuretics
Sodium Potassium Chloride Symporter Inhibitors
Sulfonamides
Anuria
CYP2C8 protein, human
CYP2C9 protein, human
Congestive heart failure
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Narrower (1)
Luprac
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects.
B. Lopez
,
Arantxa González
,
N. Hermida
,
F. Valencia
,
E. de Teresa
,
J. Díez
American journal of physiology. Heart and…
2010
Corpus ID: 12200203
Because of its dynamic nature, the composition and structure of the myocardial collagen network can be reversibly modified to…
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Review
2009
Review
2009
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.
Shufeng Zhou
,
Zhi-Wei Zhou
,
Li-Ping Yang
,
Jian Cai
Current medicinal chemistry
2009
Corpus ID: 23652032
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100…
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Highly Cited
2004
Highly Cited
2004
Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure.
B. Lopez
,
R. Querejeta
,
Arantxa González
,
E. Sánchez
,
M. Larman
,
J. Díez
Journal of the American College of Cardiology
2004
Corpus ID: 22680024
Highly Cited
2004
Highly Cited
2004
Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor
Yuping Chen
,
S. Ferguson
,
M. Negishi
,
J. Goldstein
Journal of Pharmacology and Experimental…
2004
Corpus ID: 11277721
Human CYP2C9 is important in the metabolism of numerous clinically used drugs such as the anticoagulant warfarin, the…
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Highly Cited
2002
Highly Cited
2002
Torasemide in chronic heart failure: results of the TORIC study
J. Cosín
,
J. Díez
European journal of heart failure
2002
Corpus ID: 21866721
Highly Cited
1999
Highly Cited
1999
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.
U. Yasar
,
E. Eliasson
,
M. Dahl
,
I. Johansson
,
M. Ingelman-Sundberg
,
F. Sjöqvist
Biochemical and biophysical research…
1999
Corpus ID: 12935015
Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan…
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Review
1999
Review
1999
Effects of Liver Disease on Pharmacokinetics
V. Rodighiero
Clinical pharmacokinetics
1999
Corpus ID: 46831071
Liver disease can modify the kinetics of drugs biotransformed by the liver. This review updates recent developments in this field…
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Review
1998
Review
1998
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.
J. Miners
,
D. Birkett
British journal of clinical pharmacology
1998
Corpus ID: 2495124
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for…
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Highly Cited
1997
Highly Cited
1997
Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study.
I. Shilliday
,
K. J. Quinn
,
M. Allison
Nephrology, dialysis, transplantation : official…
1997
Corpus ID: 99136
BACKGROUND Studies on the role of loop diuretics in patients with acute renal failure (ARF) are largely retrospective, anecdotal…
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Highly Cited
1994
Highly Cited
1994
Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure.
D. Fliser
,
M. Schröter
,
M. Neubeck
,
E. Ritz
Kidney international
1994
Corpus ID: 30578671
It is commonly assumed that thiazide diuretics are ineffective in patients with advanced renal failure (GFR < 30 ml/min/1.73 m2…
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