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torsemide

Known as: 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, Torasemidum, 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea 
An anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (4)

Antihypertensive AgentsDiureticsSodium Potassium Chloride Symporter InhibitorsSulfonamides
AnuriaCYP2C8 protein, humanCYP2C9 protein, humanCongestive heart failure

Narrower (1)

Luprac

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects.
Because of its dynamic nature, the composition and structure of the myocardial collagen network can be reversibly modified to… 
Review
2009
Review
2009
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100… 
Highly Cited
2004
Highly Cited
2004
Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure.
Highly Cited
2004
Highly Cited
2004
Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor
Human CYP2C9 is important in the metabolism of numerous clinically used drugs such as the anticoagulant warfarin, the… 
Highly Cited
2002
Highly Cited
2002
Torasemide in chronic heart failure: results of the TORIC study
Highly Cited
1999
Highly Cited
1999
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.
Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan… 
Review
1999
Review
1999
Effects of Liver Disease on Pharmacokinetics
Liver disease can modify the kinetics of drugs biotransformed by the liver. This review updates recent developments in this field… 
Review
1998
Review
1998
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for… 
Highly Cited
1997
Highly Cited
1997
Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study.
BACKGROUND Studies on the role of loop diuretics in patients with acute renal failure (ARF) are largely retrospective, anecdotal… 
Highly Cited
1994
Highly Cited
1994
Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure.
It is commonly assumed that thiazide diuretics are ineffective in patients with advanced renal failure (GFR < 30 ml/min/1.73 m2… 
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