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torsemide

Known as: 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, Torasemidum, 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea 
An anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop… 
National Institutes of Health

Related topics

Related topics

23 relations

Broader (4)

Antihypertensive AgentsDiureticsSodium Potassium Chloride Symporter InhibitorsSulfonamides
AnuriaCYP2C8 protein, humanCYP2C9 protein, humanCongestive heart failure

Narrower (1)

Luprac

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions
The risk assessment of organic anion transporting polypeptide (OATP) 1B1–mediated drug-drug interactions (DDIs) is an… 
Review
2010
Review
2010
Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects.
Because of its dynamic nature, the composition and structure of the myocardial collagen network can be reversibly modified to… 
Review
2009
Review
2009
Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.
Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human liver. CYP2C9 metabolizes more than 100… 
Highly Cited
2009
Highly Cited
2009
Impact of Treatment on Myocardial Lysyl Oxidase Expression and Collagen Cross-Linking in Patients With Heart Failure
The aim of this study was to investigate whether torasemide modifies collagen cross-linking in the failing human heart. We… 
Highly Cited
2007
Highly Cited
2007
Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure.
Highly Cited
2004
Highly Cited
2004
Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure.
Highly Cited
2004
Highly Cited
2004
Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor
Human CYP2C9 is important in the metabolism of numerous clinically used drugs such as the anticoagulant warfarin, the… 
Highly Cited
1999
Highly Cited
1999
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.
Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan… 
Highly Cited
1997
Highly Cited
1997
Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.
Omeprazole 5-hydroxylation and sulfoxidation activities were determined in liver microsomes of different humans whose levels of… 
Highly Cited
1994
Highly Cited
1994
Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure.
It is commonly assumed that thiazide diuretics are ineffective in patients with advanced renal failure (GFR < 30 ml/min/1.73 m2… 
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