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torsemide

Known as: 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea, Torasemidum, 1-isopropyl-3-((4-(3-methylphenylamino)pyridine)-3-sulfonyl)urea 
An anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop… Expand
National Institutes of Health

Related topics

Related topics

23 relations

Broader (4)

Antihypertensive AgentsDiureticsSodium Potassium Chloride Symporter InhibitorsSulfonamides
AnuriaCYP2C8 protein, humanCYP2C9 protein, humanCongestive heart failure
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Narrower (1)

Luprac

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Comparing Generic Drug Markets in Europe and the United States: Prices, Volumes, and Spending
Policy Points: Our study indicates that there are opportunities for cost savings in generic drug markets in Europe and the United… Expand
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Highly Cited
2004
Highly Cited
2004
Effects of loop diuretics on myocardial fibrosis and collagen type I turnover in chronic heart failure.
OBJECTIVES This individually randomized, open-label, parallel-group pilot study was designed to test the hypothesis that the… Expand
Highly Cited
2004
Highly Cited
2004
Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor
Human CYP2C9 is important in the metabolism of numerous clinically used drugs such as the anticoagulant warfarin, the… Expand
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Highly Cited
2002
Highly Cited
2002
Torasemide in chronic heart failure: results of the TORIC study
Diuretics such as torasemide are commonly used to treat chronic heart failure (CHF). 
Highly Cited
2001
Highly Cited
2001
Open-label randomized trial of torsemide compared with furosemide therapy for patients with heart failure.
PURPOSE Because the bioavailability of oral furosemide is erratic and often incomplete, we tested the hypothesis that patients… Expand
Highly Cited
1999
Highly Cited
1999
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.
Cytochrome P450 2C9 (CYP2C9) catalysis the metabolism of important drugs such as phenytoin, S-warfarin, tolbutamide, losartan… Expand
Review
1998
Review
1998
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism.
Accumulating evidence indicates that CYP2C9 ranks amongst the most important drug metabolizing enzymes in humans. Substrates for… Expand
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Highly Cited
1997
Highly Cited
1997
Loop diuretics in the management of acute renal failure: a prospective, double-blind, placebo-controlled, randomized study.
BACKGROUND Studies on the role of loop diuretics in patients with acute renal failure (ARF) are largely retrospective, anecdotal… Expand
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Highly Cited
1995
Highly Cited
1995
Bioavailability, pharmacokinetics, and pharmacodynamics of torsemide and furosemide in patients with congestive heart failure
The bioavailability, pharmacokinetics, and pharmacodynamics of torsemide (10 mg orally and intravenously) and furosemide (40 mg… Expand
Highly Cited
1994
Highly Cited
1994
Coadministration of thiazides increases the efficacy of loop diuretics even in patients with advanced renal failure.
It is commonly assumed that thiazide diuretics are ineffective in patients with advanced renal failure (GFR < 30 ml/min/1.73 m2… Expand
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