Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
- T. Asahara, T. Murohara, J. Isner
- Biology, MedicineScience
- 14 February 1997
It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
- E. Tateishi-Yuyama, H. Matsubara, T. Imaizumi
- Medicine, BiologyThe Lancet
- 10 August 2002
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
- T. Murohara, T. Asahara, J. Isner
- BiologyJournal of Clinical Investigation
- 28 February 1998
It is suggested that defective endothelial NO synthesis may limit angiogenesis in patients with endothelial dysfunction related to atherosclerosis, and that oral L-arginine supplementation constitutes a potential therapeutic strategy for accelerating angiogenic in Patients with advanced vascular obstruction.
Mobilization of Endothelial Progenitor Cells in Patients With Acute Myocardial Infarction
- S. Shintani, T. Murohara, T. Imaizumi
- Biology, MedicineCirculation
- 12 June 2001
This is the first clinical demonstration showing that lineage-committed EPCs and MNCCD34+, their putative precursors, are mobilized during an acute ischemic event in humans.
Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization.
- T. Murohara, H. Ikeda, T. Imaizumi
- Biology, MedicineJournal of Clinical Investigation
- 1 June 2000
It is revealed that in vivo transplantation of cord blood-derived EPCs represents a promising strategy for modulating postnatal neovascularization and laser Doppler and immunohistochemical analyses revealed that EPC transplantation quantitatively augmented neov vascularization and blood flow in the ischemic hindlimb.
Age-dependent impairment of angiogenesis.
Angiogenesis responsible for collateral development in limb ischemia is impaired with aging; responsible mechanisms include age-related endothelial dysfunction and reduced VEGF expression.
Implantation of Bone Marrow Mononuclear Cells Into Ischemic Myocardium Enhances Collateral Perfusion and Regional Function via Side Supply of Angioblasts, Angiogenic Ligands, and Cytokines
- H. Kamihata, Hiroaki Matsubara, T. Iwasaka
- Medicine, BiologyCirculation
- 28 August 2001
BMI may constitute a novel safety strategy for achieving optimal therapeutic angiogenesis by the natural ability of the BM cells to secrete potent angiogenic ligands and cytokines as well as to be incorporated into foci of neovascularization.
Idiopathic Ventricular Arrhythmias Originating From the Left Ventricular Summit: Anatomic Concepts Relevant to Ablation
- Takumi Yamada, H. T. McElderry, G. Kay
- Medicine, BiologyCirculation: Arrhythmia and Electrophysiology
- 1 December 2010
LV summit VAs may be ablated within the GCV or inferior to theGCV on the epicardial surface, though sites superior to the GCv are usually inaccessible to ablation.
H2S Protects Against Pressure Overload–Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase
- Kazuhisa Kondo, S. Bhushan, D. Lefer
- Biology, MedicineCirculation
- 12 March 2013
H2S levels are decreased in mice in the setting of heart failure, and oral H2S therapy prevents the transition from compensated to decompensated heart failure in part via upregulation of endothelial nitric oxide synthase and increased Nitric oxide bioavailability.
Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin.
- T. Murohara, J. Horowitz, J. Isner
- Biology, MedicineCirculation
- 13 January 1998
These results implicate NO and prostacyclin produced by the interaction of VEGF/VPF with its Flk-1/KDR/VEGF-R2 receptor as mediators of V EGF/ VPF-induced vascular permeability, and this property appears unique to VEGFs among angiogenic cytokines.
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