tolrestat

Known as: N-((5-(trifluoromethyl)-6-methoxy-1-naphthalenyl)thioxomethyl)-N-methylglycine, N-5-trifluoromethyl-6-methoxy-1-thionaphthoyl-N-methylglycine, Glycine, N-((6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)thioxomethyl)-N-methyl- 
 
National Institutes of Health

Papers overview

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1996
1996
Hyperglycemia is of central importance in the pathogenesis of the complications of diabetes mellitus. Glucose activation of the… (More)
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1995
1995
OBJECTIVE To compare the effects of tolrestat and placebo in patients with subclinical diabetic neuropathy. RESEARCH DESIGN AND… (More)
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1994
1994
The clinical efficacy of an aldose reductase (AR) inhibitor in diabetic polyneuropathy depends on its bioavailability at the site… (More)
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1993
1993
A double-blind, placebo-controlled clinical trial was conducted to study the effects of discontinuing tolrestat, an aldose… (More)
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1993
1993
Diabetes mellitus causes widespread damage of the peripheral nervous system, involving chiefly the somatic sensory and autonomic… (More)
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1993
1993
OBJECTIVE To explore the possible link between diabetic nephropathy and the enhanced activity of the polyol pathway, known to… (More)
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1991
1991
The progressive increase in urinary albumin excretion, which precedes the development of diabetic nephropathy, can be prevented… (More)
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1990
1990
The effects of the aldose-reductase inhibitor, tolrestat, on chronic symptomatic diabetic sensorimotor neuropathy were studied… (More)
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1989
1989
The earliest histopathologic signs of diabetic retinopathy include selective loss of intramural pericytes and thickening of… (More)
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1986
1986
A diabetic-like thickening of retinal capillary basement membranes induced in rats fed for 207 consecutive days a diet containing… (More)
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