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tofenacin

Known as: N-methyl-2-(o-methyl-alpha-phenylbenzyloxy)ethyl amine, demethylorphenadrine, tofenacine 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Cholinergic AntagonistsDisipalOrphenadrine

Narrower (2)

Elamoltofenacin hydrochloride
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1989
1989
Residual Neuroleptic-Induced Parkinsonian Symptoms in Schizophrenia
A naturalistic study was performed on 44 schizophrenic outpatients diagnosed according to DSM III-R and presenting neuroleptic… 
1988
1988
Identification of structural characteristics of some potential H2-receptor antagonists that determine the interaction with rat hepatic P-450.
1987
1987
Cytochrome P450 metabolic intermediate complex of nefopam
NADPH‐catalysed biotransformation of nefopam in liver microsomes obtained from phenobarbitone‐pretreated rats leads to the… 
1984
1984
Inhibition of mono-oxygenase and oxidase activity of rat-hepatic cytochrome P-450 by H2-receptor blockers.
Of four H2 blockers, cimetidine, tiotidine, oxmetidine and ranitidine, all except ranitidine showed ligand (type II) interactions… 
1983
1983
Product inhibition in orphenadrine metabolism as a result of a stable cytochrome P-450-metabolic intermediate complex formed during the disposition of mono-N-desmethylorphenadrine (tofenacine) in the…
Product inhibition is thought to be involved in unexpected accumulation of orphenadrine, which occurs during chronic medication… 
1982
1982
Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat.
1978
1978
A Comparison of the inhibitory effects of aromatic substituted benzhydryl ethers on the uptake of catecholamines and serotonin into synaptosomal preparations of the rat brain
1971
1971
An evaluation of tofenacine (elamol), a new drug for the treatment of depression.
1968
1968
The concentrations of orphenadrine and its N-demethylated derivatives in rat brain, after intraperitoneal administration of orphenadrine and tofenacine.
1966
1966
The effect of orphenadrine and its N-demethyl derivative on the level of 5-hydroxytryptamine in rat brain.
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