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Health effects of quercetin: from antioxidant to nutraceutical.
The mechanism by which quercetin may operate as an antioxidant as well as the potential use of this antioxidant as a nutraceutical (tested both ex vivo and in vivo) will be discussed. Expand
The pharmacology of the antioxidant lipoic acid.
Within drug-related antioxidant pharmacology, lipoic acid is a model compound that enhances understanding of the mode of action of antioxidants in drug therapy. Expand
Structural aspects of antioxidant activity of flavonoids.
It can be concluded that Ep/2 values and iron chelating activity can almost completely describe the LPO inhibiting behaviour of the flavonoids. Expand
Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group.
Increased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease.
It is demonstrated that patients with stable COPD exhibit increased oxidant production in the airways and that oxidantProduction increases further during exacerbations. Expand
Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures
The TEAC (Trolox equivalent antioxidant capacity) assay is based on scavenging of 2,2'-azinobis-(3- ethylbenzothiazoline-6-sulfonate) radical anions (ABTS(.-)). In this report we describe aExpand
Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay.
The experiments show that the TEAC is the antioxidant capacity of the parent compound plus the potential antioxidantcapacity of the reaction product(s), which hampers the applicability of the assay for the construction of SARs and for ranking antioxidants. Expand
Oxidants and antioxidants: state of the art.
In the development of new antioxidant therapies, the important question of how these drugs are incorporated in or commensurate with existing integrated physiologic radical-defense systems should be addressed. Expand
The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.
Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone, a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Expand
ATP-mediated Activation of the NADPH Oxidase DUOX1 Mediates Airway Epithelial Responses to Bacterial Stimuli*
The results indicate that ATP-mediated DUOX1 activation represents a common response mechanism to several environmental stimuli, involving H2O2-dependent EGFR/ERK activation, ADAM17 activation, and EGFR ligand shedding, leading to amplified epithelial EGFR activation and IL-8 production. Expand