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Orphenadrine

Known as: ?-dimethylaminoethyl 2-methylbenzhydryl ether, 2-(phenyl-o-tolylmethoxy)ethyldimethylamine, Phenyl-O-tolylmethyl dimethyaminoethyl ether 
A muscarinic antagonist with muscle relaxant activity. Although the mechanism of action has not been determined, orphenadrine appears to block… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
Health care providers prescribe skeletal muscle relaxants for a variety of indications. However, the comparative efficacy of… 
Highly Cited
2004
Highly Cited
2004
The subthalamic nucleus (STN) has a key role in the pathophysiology of Parkinson's disease and is the primary target for high… 
Review
2004
Review
2004
Skeletal muscle relaxants are a heterogeneous group of medications used to treat two different types of underlying conditions… 
Highly Cited
2002
Highly Cited
2002
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many… 
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Highly Cited
1999
Highly Cited
1999
Abstract Nicotine C-oxidation by recombinant human cytochrome P450 (P450 or CYP) enzymes and by human liver microsomes was… 
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Highly Cited
1998
Highly Cited
1998
Background Drug eruptions are among the most common cutaneous disorders encountered by the dermatologist. Some drug eruptions… 
Highly Cited
1997
Highly Cited
1997
The specificities of orphenadrine and methimazole on eight human liver P450 enzyme activities were evaluated by studying the… 
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Highly Cited
1993
Highly Cited
1993
The present study identifies the specific human cytochrome P-450 (CYP) enzymes involved in hydroxylation leading to activation of… 
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Highly Cited
1990
Highly Cited
1990
Several studies support the hypothesis of 5-HT (serotonin) involvement in the physiopathology of the extrapyramidal system… 
Highly Cited
1987
Highly Cited
1987
&NA; The formalin test in mice is a valid and reliable model of nociception and is sensitive for various classes of analgesic…