Orphenadrine

Known as: ?-dimethylaminoethyl 2-methylbenzhydryl ether, 2-(phenyl-o-tolylmethoxy)ethyldimethylamine, Phenyl-O-tolylmethyl dimethyaminoethyl ether 
A muscarinic antagonist with muscle relaxant activity. Although the mechanism of action has not been determined, orphenadrine appears to block… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
The subthalamic nucleus (STN) has a key role in the pathophysiology of Parkinson's disease and is the primary target for high… (More)
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Highly Cited
2003
Highly Cited
2003
Despite several studies and models, much remains unclear about how the human basal ganglia operate. Deep brain stimulation (DBS… (More)
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Highly Cited
2002
Highly Cited
2002
Ketamine is a widely used drug for its anesthetic and analgesic properties; it is also considered as a drug of abuse, as many… (More)
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Highly Cited
1999
Highly Cited
1999
Nicotine C-oxidation by recombinant human cytochrome P450 (P450 or CYP) enzymes and by human liver microsomes was investigated… (More)
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1997
1997
The specificities of orphenadrine and methimazole on eight human liver P450 enzyme activities were evaluated by studying the… (More)
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1995
1995
Orphenadrine has been used as an antiparkinsonian, antispastic and analgesic drug for many years. Here we show that orphenadrine… (More)
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Highly Cited
1993
Highly Cited
1993
The present study identifies the specific human cytochrome P-450 (CYP) enzymes involved in hydroxylation leading to activation of… (More)
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1989
1989
The anti-parkinsonian agent orphenadrine has been shown to form an in vitro metabolic intermediate (MI) complex in hepatic… (More)
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Highly Cited
1987
Highly Cited
1987
The formalin test in mice is a valid and reliable model of nociception and is sensitive for various classes of analgesic drugs… (More)
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1985
1985
From January 1974 to June 1983, the Paris Poison Control Centre collected 84 cases of overdosage with orphenadrine alone or in… (More)
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