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tipranavir

Known as: 3'-((1R)-1-((6R)-5,6-dihydro-4-hydroxy-2-oxo-6-phenethyl-6-propyl-2h-pyran-3-yl)propyl)-5-(trifluoromethyl)-2-pyridinesulfonanilide, tipranavir [Chemical/Ingredient] 
A non-peptidomimetic agent that inhibits both wild type and drug resistant forms of human immunodeficiency virus (HIV) protease.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
In 2008, 25 years after the human immunodeficiency virus (HIV) was discovered as the then tentative aetiological agent of… Expand
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2009
2009
To identify pharmacokinetic (PK) drug-drug interactions between tipranavir-ritonavir (TPV/r) and rosuvastatin and atorvastatin… Expand
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2008
2008
To identify mutations associated with the virological response (VR) to a tipranavir-ritonavir (TPV/r)-based regimen, 143 patients… Expand
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2007
2007
Drug resistance is a major problem affecting the clinical efficacy of antiretroviral agents, including protease inhibitors, in… Expand
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Highly Cited
2006
Highly Cited
2006
Highly Cited
2006
Tipranavir is a novel, nonpeptidic protease inhibitor of human immunodeficiency virus type 1 (HIV-1) with activity against… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Improved treatment options are needed for patients infected with multidrug-resistant human immunodeficiency virus type… Expand
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2005
2005
Tipranavir is a novel, non-peptidic protease inhibitor, which possesses broad antiviral activity against multiple protease… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE Although the use of HIV-1 protease inhibitors (PI) has substantially benefited HIV-1-infected individuals, new PI are… Expand
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Highly Cited
1998
Highly Cited
1998
A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease… Expand
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