tick anticoagulant peptide
National Institutes of Health
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The structure of tick anticoagulant peptide (TAP) has been determined by X‐ray crystallography at 1.6 Å resolution complexed with…
Summary We investigated whether the direct fXa inhibitor tick anticoagulant peptide (TAP) can be N-terminally coupled to a clot…
In the presence of denaturant and thiol catalyst, a disulfide-containing protein denatures and converts to a mixture of scrambled…
The pathway of oxidative folding of tick anticoagulant peptide (TAP, 60 amino acids and three disulfides) has been analyzed by…
Progression of arterial thrombosis partly depends on thrombus-associated thrombin and activated factor X (Xa) activity. However…
Ornithodorin, isolated from the blood sucking soft tick Ornithodoros moubata, is a potent (Ki = 10(‐12) M) and highly selective…
Tick anticoagulant peptide (TAP) is a potent and selective 60‐amino acid inhibitor of the serine protease Factor Xa (fXa), the…
Tick anticoagulant peptide (TAP) is a potent and specific inhibitor of the blood coagulation protease Factor Xa. We designed and…
Tick anticoagulant peptide (TAP) is a 60 amino acid peptide (Mr=6977, pI=4.9) found in the saliva of the soft tick Ornithodorous…