thiopurine S-methyltransferase activity

Known as: mercaptopurine methyltransferase activity, TPMT, thiopurine methyltransferase activity 
Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. [EC:2.1.1.67]
National Institutes of Health

Papers overview

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2004
2004
Thiopurine drugs are commonly used in pediatric patients for the treatment of acute leukemia, organ transplantation and… (More)
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2002
2002
This study examined the role of thiopurine methyltransferase (TPMT) polymorphism in the metabolism and clinical effects of… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Measurement of 6-thioguanine nucleotide concentrations may be useful for optimising treatment with azathioprine and 6… (More)
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2001
2001
AIMS Inherited differences in thiopurine methyltransferase (TPMT) activity are an important factor in the wide interindividual… (More)
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Highly Cited
1999
Highly Cited
1999
Thiopurine methyltransferase metabolizes 6-mercaptopurine, thioguanine and azathioprine, thereby regulating cytotoxicity and… (More)
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1999
1999
Objectives: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT… (More)
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Highly Cited
1998
Highly Cited
1998
Azathioprine has demonstrated disease-modifying activity in rheumatic disease and is an effective therapy for inflammatory bowel… (More)
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1992
1992
A number of metabolic pathways are subject to both genetic polymorphism and interethnic differences. A catabolic pathway of 6… (More)
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1992
1992
The immunosuppressive efficacy of azathioprine is related to its rapid metabolism in vivo to 6-mercaptopurine (6MP), with… (More)
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Highly Cited
1987
Highly Cited
1987
Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and… (More)
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