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thiopurine S-methyltransferase activity

Known as: mercaptopurine methyltransferase activity, TPMT, thiopurine methyltransferase activity 
Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. [EC:2.1.1.67]
National Institutes of Health

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TPMT geneThiopurine S-Methyltransferase

Papers overview

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Highly Cited
2011
Highly Cited
2011
Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS)
In this contribution, the great potential of surface enhanced Raman spectroscopy (SERS) in a lab-on-a-chip (LOC) device for the… 
Review
2010
Review
2010
Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.
OBJECTIVES To examine whether pretreatment determination of thiopurine methyltransferase (TPMT) enzymatic activity (phenotyping… 
2008
2008
Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.
2001
2001
High 6-Thioguanine Nucleotide Levels and Low Thiopurine Methyltransferase Activity in Patients With Lupus Erythematosus Treated With Azathioprine
Azathioprine (AZA) is characterized by a high interindividual variability in bioavailability and metabolism. AZA is converted… 
2000
2000
Demonstration of Thiopurine Methyltransferase Activity in the Erythrocytes of Cats
Azathioprine is a purine analogue used as an immunosuppressive and immunomodulator agent in various mammals, including cats… 
1997
1997
Thiopurine methyltransferase activity: new high-performance liquid chromatographic assay conditions.
1995
1995
Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients.
Thiopurine methyltransferase (TPMT), one of the enzymes involved in azathioprine metabolism, exhibits a wide range of activity in… 
1995
1995
[Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation].
Azathioprine is an immunosuppressor used with ciclosporin and corticosteroids after organ transplantation. Azathioprine is… 
Highly Cited
1994
Highly Cited
1994
High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity.
1993
1993
Fast and slow methylators: do racial differences influence risk of allograft rejections?
A catabolic route for azathioprine involving methylation by thiopurine methyltransferase has been directly implicated in the drug… 
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