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thiopurine S-methyltransferase activity
Known as:
mercaptopurine methyltransferase activity
, TPMT
, thiopurine methyltransferase activity
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Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. [EC:2.1.1.67]
National Institutes of Health
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Related topics
Related topics
2 relations
TPMT gene
Thiopurine S-Methyltransferase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS)
Anne März
,
B. Mönch
,
P. Rösch
,
M. Kiehntopf
,
T. Henkel
,
J. Popp
Analytical and Bioanalytical Chemistry
2011
Corpus ID: 20507596
In this contribution, the great potential of surface enhanced Raman spectroscopy (SERS) in a lab-on-a-chip (LOC) device for the…
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Review
2011
Review
2011
Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review.
E. Loit
,
A. Tricco
,
Sophia Tsouros
,
M. Sears
,
M. Ansari
,
R. Booth
Clinical Biochemistry
2011
Corpus ID: 46215209
Review
2010
Review
2010
Assessment of thiopurine methyltransferase activity in patients prescribed azathioprine or other thiopurine-based drugs.
Ronald A. Booth
,
M. Ansari
,
+15 authors
F. Yazdi
Evidence report/technology assessment
2010
Corpus ID: 35507762
OBJECTIVES To examine whether pretreatment determination of thiopurine methyltransferase (TPMT) enzymatic activity (phenotyping…
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2008
2008
Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.
Lola Y. Kwan
,
S. Devlin
,
J. Mirocha
,
K. Papadakis
Digestive and Liver Disease
2008
Corpus ID: 42281156
2001
2001
High 6-Thioguanine Nucleotide Levels and Low Thiopurine Methyltransferase Activity in Patients With Lupus Erythematosus Treated With Azathioprine
G. Decaux
,
Y. Horsmans
,
F. Houssiau
,
J. Desager
American Journal of Therapeutics
2001
Corpus ID: 22485508
Azathioprine (AZA) is characterized by a high interindividual variability in bioavailability and metabolism. AZA is converted…
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2000
2000
Demonstration of Thiopurine Methyltransferase Activity in the Erythrocytes of Cats
A. Foster
,
S. Shaw
,
J. Duley
,
E. Shobowale-Bakre
,
D. Harbour
2000
Corpus ID: 196399458
Azathioprine is a purine analogue used as an immunosuppressive and immunomodulator agent in various mammals, including cats…
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1997
1997
Thiopurine methyltransferase activity: new high-performance liquid chromatographic assay conditions.
Y. Médard
,
S. Nafa
,
É. Jacqz-Aigrain
Journal of Chromatography B: Biomedical Sciences…
1997
Corpus ID: 20799875
1996
1996
Intraindividual variability in red blood cell thiopurine methyltransferase activity
T. Giverhaug
,
B. Klemetsdal
,
R. Lysaa
,
J. Aarbakke
European Journal of Clinical Pharmacology
1996
Corpus ID: 5737084
Objective: Long-term (13 weeks) and circadian (24 hours) intraindividual variability in red blood cell (RBC) thiopurine…
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1995
1995
Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients.
J. Mircheva
,
C. Legendre
,
C. Soria-Royer
,
E. Thervet
,
P. Beaune
,
H. Kreis
Transplantation
1995
Corpus ID: 45698169
Thiopurine methyltransferase (TPMT), one of the enzymes involved in azathioprine metabolism, exhibits a wide range of activity in…
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1995
1995
[Hematotoxicity caused by azathioprine genetically determined and aggravated by xanthine oxidase deficiency in a patient following renal transplantation].
F. Serre-Debeauvais
,
F. Bayle
,
+4 authors
G. Bessard
Presse medicale
1995
Corpus ID: 45682834
Azathioprine is an immunosuppressor used with ciclosporin and corticosteroids after organ transplantation. Azathioprine is…
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