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Macrocycles are appealing drug candidates due to their high affinity, specificity, and favorable pharmacological properties. In… Expand Significance Thiazolyl peptides are known antibiotics produced by diverse bacterial taxa. It has been believed that antibiotics… Expand Thiocillins from Bacillus cereus ATCC 14579 are members of the well-known thiazolyl peptide class of natural product antibiotics… Expand The thiocillins from Bacillus cereus ATCC 14579 are natural products from the broader class of thiazolyl peptides. Their… Expand The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure… Expand Bacillus cereus ATCC 14579 converts the C-terminal 14 residues of a 52-mer prepeptide into a related set of eight variants of the… Expand The thiazolylpeptides are a family of >50 bactericidal antibiotics that block the initial steps of bacterial protein synthesis… Expand The thiocillins are natural-product antibiotics derived from ribosomally encoded peptides that undergo extensive… Expand Thiopeptides, with potent activity against various drug-resistant pathogens, contain a characteristic macrocyclic core consisting… Expand The present research examined diurnal variation in the severity of symptoms of experimentally-induced colds and influenza. Nasal… Expand