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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. TheExpand
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Word and tone working memory deficits in schizophrenia.
BACKGROUND Verbal memory deficits have been reported in many studies of patients with schizophrenia. We evaluated the specificity of these deficits by comparing patients and control subjects onExpand
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Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
The efficient total synthesis of the recently described natural substance largazole (1) and its active metabolite largazole thiol (2) is described. The synthesis required eight linear steps andExpand
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Functional MR imaging of regional brain responses to pleasant and unpleasant odors.
BACKGROUND AND PURPOSE Odors can elicit a range of behaviors and emotions. Our purpose was to identify regional activation of the human cerebral cortex in response to pleasant (positive hedonicExpand
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Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.
Bacillus cereus ATCC 14579 converts the C-terminal 14 residues of a 52-mer prepeptide into a related set of eight variants of the thiocillin subclass of thiazolyl peptide antibiotics by a cascade ofExpand
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Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.
The thiocillins are natural-product antibiotics derived from ribosomally encoded peptides that undergo extensive posttranslational modifications to yield the mature trithiazolylpyridine-containingExpand
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Structural Insights into Thioether Bond Formation in the Biosynthesis of Sactipeptides.
Sactipeptides are ribosomally synthesized peptides that contain a characteristic thioether bridge (sactionine bond) that is installed posttranslationally and is absolutely required for theirExpand
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A Backup Plan for Self‐Protection: S‐Methylation of Holomycin Biosynthetic Intermediates in Streptomyces clavuligerus
Biosynthesis of the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus involves the closure of a pair of enethiols to a cyclic disulfide. We have shown that the dithiol oxidase HlmIExpand
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Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.
Fourteen analogs of the marine natural product largazole have been prepared and assayed against histone deacetylases (HDACs) 1, 2, 3, and 6. Olefin cross-metathesis was used to efficiently access sixExpand
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Thiazolyl Peptide Antibiotic Biosynthesis: A Cascade of Post-translational Modifications on Ribosomal Nascent Proteins*
Antibiotics of the thiocillin, GE2270A, and thiostrepton class, which block steps in bacterial protein synthesis, contain a trithiazolyl (tetrahydro)pyridine core that provides the architecturalExpand
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