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tetrahydropterin

 
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
BackgroundDopamine is a catecholamine that is used as a neurotransmitter both in the periphery and in the central nervous system… Expand
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Highly Cited
2008
Highly Cited
2008
Dioxygen activation by mononuclear iron oxygenases in general requires two electrons and protons to facilitate the reductive… Expand
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2003
2003
Tetrahydrobiopterin (BH(4)) is a cofactor for aromatic amino acid hydroxylases and nitric oxide synthase. The biosynthesis… Expand
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Highly Cited
1999
Highly Cited
1999
The mammalian aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan hydroxylase (PheOH, TyrOH, TrpOH… Expand
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1999
1999
The enzyme 6-pyruvoyl tetrahydropterin synthase (PTPS) catalyses the second step in the de novo biosynthesis of… Expand
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1998
1998
Human tyrosine hydroxylase exists as four isoforms (hTH1–4), generated by alternative splicing of pre-mRNA, with tissue-specific… Expand
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1994
1994
The crystal structure of rat liver 6‐pyruvoyl tetrahydropterin synthase has been solved by multiple isomorphous replacement and… Expand
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Highly Cited
1993
Highly Cited
1993
Stimulation of nitric oxide (NO) synthase in endothelial cells by Ca2+ influx leads to increased intracellular levels of cGMP. NO… Expand
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1991
1991
We describe the clinical, neurologic, and biochemical findings in 10 patients with 6‐pyruvoyl tetrahydropterin synthase (6‐PTS… Expand
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Highly Cited
1990
Highly Cited
1990
Interferon-gamma induces tetrahydrobiopterin biosynthesis in human cells and cell lines. Macrophages are peculiar in the… Expand
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