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Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
It is estimated that 8,300 independent, mostly common SNPs contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability.
Genome-wide association study identifies five new schizophrenia loci
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia.
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
The efficient re-expression of electrophysiologically responsive, ligand-binding nicotinic acetylcholine receptors in dopamine-containing neurons of the VTA is demonstrated, together with the recovery of nicotine-elicited dopamine release and nicotine self-administration.
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
- F. Côté, E. Thévenot, G. Vodjdani
- BiologyProceedings of the National Academy of Sciences…
- 3 November 2003
It is established that the neuronal tph2 is expressed in neurons of the raphe nuclei and of the myenteric plexus, whereas the nonneuronal tph1, as detected by β-galactosidase expression, is in the pineal gland and the enterochromaffin cells.
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.
Mitogen-activated protein-kinase (MAP) kinase-activatedprotein kinases 1 and 2, were found to phosphorylate bacterially expressed human tyrosine hydroxylase in vitro at comparable rates to other proteins thought to be physiological substrates of these protein kinases.
Maternal serotonin is crucial for murine embryonic development
- F. Côté, C. Fligny, G. Vodjdani
- Biology, PsychologyProceedings of the National Academy of Sciences
- 2 January 2007
Observations provide the first clear evidence that maternal serotonin is involved in the control of morphogenesis during developmental stages that precede the appearance of serotonergic neurons and (ii) serotonin is critical for normal murine development.
Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons
Observations suggest that constitutive gastrointestinal motility depends more on neuronal than EC cell serotonin; moreover, serotonergic neurons promote development/survival of some classes of late-born enteric neurons, including dopaminergic neurons, which appear to innervate and activate in the adult ENS.
Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
A centralized analysis pipeline was applied to a SCZ cohort of 21,094 cases and 20,227 controls and Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.
Gene networks inference using dynamic Bayesian networks
- B. Perrin, L. Ralaivola, Aurélien Mazurie, S. Bottani, J. Mallet, Florence d'Alché-Buc
- Computer ScienceECCB
- 27 September 2003
This article deals with the identification of gene regulatory networks from experimental data using a statistical machine learning approach that can be described as a dynamic Bayesian network particularly well suited to tackle the stochastic nature of gene regulation and gene expression measurement.