tenofovir alafenamide

Known as: TAF, bis{9-[(2R,5S,7E)-2,7,10-trimethyl-5,8-dioxo-5-phenoxy-3,9-dioxa-6-aza-5?5-phosphaundecan-1-yl]-9H-purin-6-aminium} (2E)-but-2-enedioate, bis{propan-2-yl N-[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]-L-alaninate} (2E)-but-2-enedioate 
 
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Despite substantial progress in the development of antiretroviral regimens that durably suppress Human Immunodeficiency Virus… (More)
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Review
2016
Review
2016
Tenofovir alafenamide (TAF) can be considered a new prodrug of tenofovir (TFV), as successor of tenofovir disoproxil fumarate… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Tenofovir disoproxil fumarate can cause renal and bone toxic effects related to high plasma tenofovir concentrations… (More)
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2015
2015
BACKGROUND & AIMS Tenofovir alafenamide, a phosphonate prodrug of tenofovir with greater plasma stability than tenofovir… (More)
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Highly Cited
2014
Highly Cited
2014
OBJECTIVES To evaluate the safety and efficacy of the novel tenofovir prodrug, tenofovir alafenamide (TAF), as part of a single… (More)
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Highly Cited
2013
Highly Cited
2013
OBJECTIVE To evaluate the antiviral activity, safety, pharmacokinetics, and pharmacokinetics/pharmacodynamics of short-term… (More)
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Highly Cited
2009
Highly Cited
2009
Tumor- or cancer-associated fibroblasts (TAFs or CAFs) from different tumors exhibit distinct angiogenic and tumorigenic… (More)
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Highly Cited
2001
Highly Cited
2001
Acetylation of histones by p300/CBP and PCAF is considered to be a critical step in transcriptional regulation. In order to… (More)
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Highly Cited
1991
Highly Cited
1991
A key step in the regulation of transcription involves interactions between promoter-selective factors and various components of… (More)
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Highly Cited
1971
Highly Cited
1971
Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called… (More)
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