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tenidap

Known as: 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide 
National Institutes of Health

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4 relations

Broader (3)

Anti-Inflammatory Agents, Non-SteroidalCyclooxygenase InhibitorsIndoles

Narrower (1)

tenidap sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Effects of the second-generation leukotriene B(4) receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice.
1998
1998
Tenidap decreases IL‐8 and monocyte chemotactic peptide‐1 (MCP‐1) mRNA expression in the synovial tissue of rabbits with antigen arthritis and in cultured synovial cells
Since IL‐8 and MCP‐1 are chemoattractant proteins that participate in the recruitment of inflammatory cells into the arthritic… 
1997
1997
The effect of tenidap on cytokines, acute-phase proteins, and virus load in human immunodeficiency virus (HIV)-infected patients: correlation between plasma HIV-1 RNA and proinflammatory cytokine…
Proinflammatory cytokines may be important in the pathogenesis of human immunodeficiency virus type 1 (HIV-1) disease. Tenidap… 
1997
1997
Disposition and metabolism of tenidap in the rat.
Tenidap is a new antirheumatic drug currently undergoing clinical evaluation. It inhibits production and activity of cytokines in… 
1997
1997
Effects of tenidap on the progression of osteoarthritic lesions in a canine experimental model. Suppression of metalloprotease and interleukin-1 activity.
OBJECTIVE To study, in vivo, the therapeutic effectiveness of tenidap, an antirheumatic drug, on the progression of lesions in an… 
1996
1996
Tenidap and other anion transport inhibitors disrupt cytolytic T lymphocyte-mediated IL-1 beta post-translational processing.
LPS-activated murine peritoneal macrophages produce IL-1 beta but externalize little mature cytokine in the absence of a… 
1995
1995
Rheumatoid arthritis treated with tenidap and piroxicam. Clinical associations with cytokine modulation by tenidap.
OBJECTIVE To compare the effects of tenidap and piroxicam on acute-phase protein and cytokine levels in the blood of rheumatoid… 
1992
1992
Simultaneous determination of tenidap and its stable isotope analog in serum by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.
A specific high-performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for… 
1991
1991
Tenidap, in contrast to several available nonsteroidal antiinflammatory drugs, potently inhibits the release of activated neutrophil collagenase.
Neutrophils contain a collagenase that is stored in a latent form within the specific granule. With cellular activation, the… 
1990
1990
Inhibition of IgE-mediated N-acetylglucosaminidase and serotonin release from rat basophilic leukemia cells (RBL-2H3) by tenidap: a novel anti-inflammatory agent.
Tenidap [(Z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H- indole-1-carboxamide] is a novel anti-inflammatory… 
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