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tenidap

Known as: 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide 
National Institutes of Health

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4 relations

Broader (3)

Anti-Inflammatory Agents, Non-SteroidalCyclooxygenase InhibitorsIndoles

Narrower (1)

tenidap sodium

Papers overview

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1998
1998
Tenidap decreases IL‐8 and monocyte chemotactic peptide‐1 (MCP‐1) mRNA expression in the synovial tissue of rabbits with antigen arthritis and in cultured synovial cells
Since IL‐8 and MCP‐1 are chemoattractant proteins that participate in the recruitment of inflammatory cells into the arthritic… 
1998
1998
Regulation of nitric oxide production by salicylates and tenidap in human OA-affected cartilage, rat chondrosarcomas and bovine chondrocytes.
OBJECTIVE To examine the effects of non-steroidal anti-inflammatory drugs (NSAIDS) on nitric oxide (NO) and prostaglandin E2… 
1997
1997
Disposition and metabolism of tenidap in the rat.
Tenidap is a new antirheumatic drug currently undergoing clinical evaluation. It inhibits production and activity of cytokines in… 
1997
1997
The effect of tenidap on cytokines, acute-phase proteins, and virus load in human immunodeficiency virus (HIV)-infected patients: correlation between plasma HIV-1 RNA and proinflammatory cytokine…
Proinflammatory cytokines may be important in the pathogenesis of human immunodeficiency virus type 1 (HIV-1) disease. Tenidap… 
1997
1997
Effects of tenidap and nonsteroidal antiinflammatory drugs on the response of cultured human T cells to interleukin 2 in rheumatoid arthritis.
Objective. To assess the effects of tenidap, a new oxindole class antiinflammatory compound, on the proliferative response of… 
1996
1996
Tenidap and other anion transport inhibitors disrupt cytolytic T lymphocyte-mediated IL-1 beta post-translational processing.
LPS-activated murine peritoneal macrophages produce IL-1 beta but externalize little mature cytokine in the absence of a… 
1993
1993
Regulation of human normal and osteoarthritic chondrocyte interleukin-1 receptor by antirheumatic drugs.
OBJECTIVE To determine the effect of antirheumatic drugs and corticosteroids on interleukin-1 receptor (IL-1R) levels in, and IL… 
1992
1992
Simultaneous determination of tenidap and its stable isotope analog in serum by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.
A specific high-performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for… 
1991
1991
Tenidap, in contrast to several available nonsteroidal antiinflammatory drugs, potently inhibits the release of activated neutrophil collagenase.
Neutrophils contain a collagenase that is stored in a latent form within the specific granule. With cellular activation, the… 
1990
1990
Inhibition of IgE-mediated N-acetylglucosaminidase and serotonin release from rat basophilic leukemia cells (RBL-2H3) by tenidap: a novel anti-inflammatory agent.
Tenidap [(Z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H- indole-1-carboxamide] is a novel anti-inflammatory… 
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