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Interspecies pharmacokinetic scaling and the Dedrick plots.
TLDR
Interspecies variations in pharmacokinetics are frequently the consequence of organisms living in different time domains, and scaling of data with respect to active mass and ideal pharmacokinetic space time removes the astronomical time dependency. Expand
Pharmacokinetics of Sertraline and its N-Demethyl Metabolite in Elderly and Young Male and Female Volunteers
TLDR
The terminal elimination half-life of sertraline was similar in young females, elderly males and elderly females and the mean steady-state area under the plasma concentration-time curve from time zero to 24 hours postdose (AUC24), but were approximately 25% lower in the young males. Expand
Cardiovascular Effectsv of Convulsant and Supraconvulsant Doses of Amide Local Anesthetics
TLDR
It is concluded that cats survive at least 2 times the convulsant dose of amide local anesthetics, provided oxygenation and ventilation are supported. Expand
Metabolism and disposition of the 5-hydroxytryptamine uptake blocker sertraline in the rat and dog.
TLDR
The whole brain concentration of sertraline in the rat is more than 40-fold higher than that in plasma, and the volume of distribution is about 25 liters/kg in the rats and dog. Expand
Characterization of a carbamic acid ester glucuronide of the secondary amine sertraline.
TLDR
It is suggested that sertraline in solution reversibly associates with CO2 before formation of sERTraline carbamoyl-O-glucuronide, a novel amine glucuronide that was identified in human plasma after the oral administration of sertRALine to each of seven subjects. Expand
Interpretation of plasma concentration-time curves after oral dosing.
TLDR
The pharmacokinetic information obtained after oral administration is examined using the two-Compartment model and the relative error in using a one-compartment model to calculate absorption rate constants for two-compartments data is evaluated. Expand
Pharmacokinetics of diazepam following multiple-dose oral administration to healthy human subjects
TLDR
Steady-state diazepam plasma concentration-time profiles suggested that once daily administration of the total daily dose at bedtime might be a satisfactory dosing regimen. Expand
Pharmacokinetics of Lidocaine in Fetal and Neonatal Lambs and Adult Sheep
TLDR
The newborn lamb is as capable as the adult of clearing lidocaine despite differences in half-lives, and metabolic clearances were the same in both, and approximated hepatic blood flow. Expand
Effect of external cardiopulmonary resuscitation on lidocaine pharmacokinetics in dogs.
TLDR
The results of this study show that lidocaine disposition is greatly altered during CPR and this is most likely due to a tremendous reduction of cardiac output and blood flow during CPR. Expand
Tocainide conjugation in humans: novel biotransformation pathway for a primary amine.
TLDR
The metabolism of tocainide, an experimental antiarrhythmic drug, was studied in humans and a compound identified as 3-(2,6-xylyl)-5-methylhydantoin was derived from the same metabolite that formed the additional toc Cainide after acid or beta-glucuronidase treatment. Expand
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