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telcagepant

Known as: N-((3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)hexahydro-1h-azepin-3- yl)-4-(2-oxo-2,3-dihydro-1H-imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AzepinesImidazoles

Narrower (1)

MK-0974

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1
CGRP is a potent vasodilator and nociceptive neuropeptide linked to migraine. CGRP receptors are heterodimers of receptor… 
2016
2016
Telcagepant—almost gone, but not to be forgotten (invited editorial related to Ho et al., 2015)
This issue of Cephalalgia contains what is likely to be one of the last reports of a clinical trial of telcagepant (1… 
2013
2013
Lack of hemodynamic interaction between CGRP-receptor antagonist telcagepant (MK-0974) and sumatriptan: Results from a randomized study in patients with migraine
Objective The objective of this article is to assess the effects of sumatriptan monotherapy, telcagepant monotherapy, and their… 
Highly Cited
2012
Highly Cited
2012
Randomized, Controlled Study of Telcagepant in Patients With Migraine and Coronary Artery Disease
Objective.— To evaluate the efficacy of telcagepant in patients with migraine and coronary artery disease. 
Review
2011
Review
2011
Excellent Tolerability But Relatively Low Initial Clinical Efficacy of Telcagepant in Migraine
(Headache 2011;51:118‐123) 
2011
2011
Effect of Telcagepant on Spontaneous Ischemia in Cardiovascular Patients in a Randomized Study
(Headache 2011;51:954‐960) 
Review
2011
Review
2011
Telcagepant: A New Therapeutic Option for Acute Migraine
Telcagepant (MK0974) is one of several calcitonin-gene-related peptide antagonists in development as a potential treatment for… 
Highly Cited
2010
Highly Cited
2010
Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT * Calcitonin gene-related peptide (CGRP) was first described as a potent vasodilator… 
Highly Cited
2010
Highly Cited
2010
Randomized, controlled trial of telcagepant over four migraine attacks
Methods: This study evaluated the calcitonin gene-related peptide (CGRP) receptor antagonist telcagepant (tablet formulation) for… 
2010
2010
Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding.
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