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Origin of pain in migraine: evidence for peripheral sensitisation
It is suggested that migraine can be explained to patients as a disorder of the brain, and that the headache originates in the sensory fibres that convey pain signals from intracranial and extracranial blood vessels. Expand
Guidelines for Controlled Trials of Prophylactic Treatment of Chronic Migraine in Adults
These Guidelines are intended to assist in the design of well-controlled clinical trials of chronic migraine in adults, and do not apply to studies in children or adolescents. Expand
Topiramate in migraine prophylaxis--results from a placebo-controlled trial with propranolol as an active control.
It is demonstrated that TPM 100 mg/d is effective in migraine prophylaxis and was better tolerated than TPM 200mg/d, and was generally comparable to PROP. Expand
Ergotamine in the acute treatment of migraine: a review and European consensus.
Ergotamine, from a medical perspective, is the drug of choice in a limited number of migraine sufferers who have infrequent or long duration headaches and are likely to comply with dosing restrictions. Expand
Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy.
Rizatriptan with its shorter time to maximum concentration (tmax) tended to produce a quicker onset of headache relief than sum atriptan and zolmitriptan, and the place of triptans compared with non-triptan drugs in migraine therapy remains to be established and further RCTs are required. Expand
Guidelines for controlled trials of drugs in migraine: Third edition. A guide for investigators
International Headache Society Clinical Trials Subcommittee members: Peer Tfelt-Hansen (chairman) (Denmark), Julio Pascual (vice-chairman) (Spain), Nabih Ramadan (vice-chairman) (USA), Carl DahlofExpand
Guidelines for Controlled Trials of Drugs in Migraine: Second Edition
Evidence-based guideline update: Pharmacologic treatment for episodic migraine prevention in adults: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the American
According to the recent American Academy of Neurology (AAN) guideline update, a drug can be recommended as possibly effective for migraine prevention if it had demonstrated efficacy in one Class IIExpand
Guidelines for Controlled Trials of Drugs in Cluster Headache : First Edition: International Headache Society Committee on Clinical Trials in Cluster Headache
The present guidelines were developed under the auspices of the International Headache Society (IHS) to facilitate high quality controlled clinical trials (CCT) in cluster headache. Quality CCT areExpand
Verapamil for Cluster Headache. Clinical Pharmacology and Possible Mode of Action
The clinical use of verapamil in cluster headache is reviewed, its possible mode of action is discussed, and several relevant drug interactions are mentioned. Expand