tautomycin

 
National Institutes of Health

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2009
2009
The biosynthetic gene cluster for tautomycin (TTM), a potent protein phosphatase (PP) inhibitor has recently been characterized… (More)
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2009
2009
Protein phosphatase 1 occurs in all tissues and regulates many pathways, ranging from cell-cycle progression to carbohydrate… (More)
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2009
2009
BACKGROUND Carcinoids are neuroendocrine (NE) tumors with limited treatment options. Raf-1 pathway activation has been shown to… (More)
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2008
2008
Tautomycin (TTM) is a highly potent and specific protein phosphatase inhibitor isolated from Streptomyces spiroverticillatus. The… (More)
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Highly Cited
2001
Highly Cited
2001
BAD is a proapoptotic member of the BCL-2 family of proteins, which play a major role in regulating apoptosis in cytokine… (More)
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Highly Cited
1997
Highly Cited
1997
Calyculin-A (CA), okadaic acid (OA), and tautomycin (TAU) are potent inhibitors of protein phosphatases 1 (PP1) and 2A (PP2A) and… (More)
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1995
1995
Several groups have reported that okadaic acid (OA) and some other tight-binding protein phosphatase inhibitors including… (More)
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Highly Cited
1992
Highly Cited
1992
Phosphatase inhibitors microcystin-LR, tautomycin, and okadaic acid caused contraction and increased 20-kDa myosin light chain… (More)
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Highly Cited
1992
Highly Cited
1992
We have used a combination of highly specific protein phosphatase inhibitors and purified mammalian protein phosphatases to show… (More)
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1988
1988
A novel antibiotic tautomycin induced many blebs on the surface of K562 human chronic myeloid leukemia cells, similar to the… (More)
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