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taurolidine

Known as: bis(1,1-dioxo-perhydro-1,2,4-thiadiazinyl-4)methane, Bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane, bis- (1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)methane 
A synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities. Taurolidine, derived from the amino… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (5)

Anti-Infective AgentsAnti-Infective Agents, LocalAntineoplastic AgentsTaurine
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Narrower (2)

TauroflexTaurolin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Synthesis of geminal bis- and tristriazoles: exploration of unconventional azide chemistry.
A range of geminal bis- and tristriazoles are presented. These rare and hardly studied compound classes were easily synthesized… 
2011
2011
In vitro screening of synergistic ascorbate-drug combinations for the treatment of malignant mesothelioma.
2008
2008
Symmetrical 1-pyrrolidineacetamide showing anti-HIV activity through a new binding site on HIV-1 integrase
AbstractAim:To characterize the functional and pharmacological features of a symmetrical 1-pyrrolidineacetamide, N,N′-(methylene… 
2005
2005
Peritoneal taurolidine lavage in children with localised peritonitis due to appendicitis
Despite aggressive surgical treatment, rational antibiotic therapy, and modern intensive care, generalised peritonitis remains a… 
2004
2004
The Effects of Taurolidine, a Novel Antineoplastic Agent, on Human Malignant Mesothelioma
Purpose: Malignant mesothelioma (MM) is a cancer with uniformly poor responses to current therapeutic regimens. This study… 
2002
2002
The antibacterial drug taurolidine induces apoptosis by a mitochondrial cytochrome c-dependent mechanism.
The antibacterial agent taurolidine (TRD) has been used as a lavage antibiotic to prevent development of peritonitis in patients… 
2000
2000
Modulation of tumor‐induced lethality after pneumoperitoneum in a mouse model
To the authors' knowledge, a generally accepted approach to prevent increased intraabdominal tumor implantation after… 
Review
1997
Review
1997
[Adjuvant therapy of peritonitis with taurolidine. Modulation of mediator liberation].
Despite aggressive surgical treatment, prompt antibiotic therapy, and modern intensive care, up to one half of patients still die… 
1993
1993
Taurolidine inhibits tumour necrosis factor (TNF) toxicity--new evidence of TNF and endotoxin synergy.
The use of recombinant tumour necrosis factor (TNF) in the treatment of solid tumours has been limited by life threatening… 
1977
1977
ORGANOBORANES IN SYNTHESIS AND ANALYSIS
Organoboranes which are important for preparative purposes include triethylborane, alkyldiboranes and in particular… 
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