• Publications
  • Influence
High-dose intravenous methotrexate for patients with nonleukemic leptomeningeal cancer: is intrathecal chemotherapy necessary?
High-dose (HD) intravenous methotrexate (MTX) as the sole treatment for neoplastic meningitis achieves prolonged cytotoxic serum MTX concentrations and CSF concentrations at least comparable to those achieved with standard i.t. therapy.
Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.
Three distinct subpopulations of tumor cells derived from a single parent strain BALB/cfC3H mammary adenocarcinoma were tested in vivo for sensitivity to cyclophosphamide, methotrexate, and 5-fluorouracil, finding marked differences in sensitivity to inhibition of cell division by the drugs.
N,N-dimethylformamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells.
It appears that N,N-dimethylformamide can reversibly effect the reversion of cultured human colon carcinoma cells to less malignant cell types.
Role of p21 in Apoptosis and Senescence of Human Colon Cancer Cells Treated with Camptothecin*
It is demonstrated that p21 was required for senescence development of HCT116 cells following treatment with low concentrations of CPT, indicating that apoptosis occurred by a p53- and p21-independent mechanism.
Taurolidine: cytotoxic and mechanistic evaluation of a novel antineoplastic agent.
Assessment of the antiproliferative activity of this agent in selected human and murine tumor cell lines found it inhibited both tumor formation and growth and increased the appearance of DNA debris in the sub-G(0)/G(1) region, an effect consistent with an induction of apoptosis.
Chemotherapy of neoplastic diseases.
Heterogeneity of cancer cells from a single human colon carcinoma.
The human colon carcinoma cell line DLD-1, established from tumor tissue obtained from a 45 year old white man with an adenocarcinoma of the sigmoid colon, was studied from the perspective of tumor heterogeneity to demonstrate differential sensitivities to chemotherapeutic agents.
Platelet-derived growth factor indirectly stimulates angiogenesis in vitro.
It is found that PDGF increased the proliferation of Mfs, as well as the production of Mf-derived endothelial cell growth factor and matrix collagen type I, which suggests that even in cases where the microvasculature lacks PDGF receptors, PDGF may accelerate capillary formation by activating connective tissue cells in the vicinity of endothelial cells.
In vivo selection of a highly metastatic cell line from a human pancreatic carcinoma in the nude mouse
It is indicated that the nude mouse provides a good model for in vivo selection of metastatic cells from human pancreatic cancer and will be valuable in the study of human Pancreatic cancer metastasis, particularly in the area of survival and growth of metastatics cells in the microenvironment of the liver.
Human microvascular endothelial cells express receptors for platelet-derived growth factor.
The discovery of functional PDGF receptors on human microvascular endothelial cells suggests a direct role for PDGF in this process of neovascularization required for wound healing and solid tumor growth.