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t(4;14)

A chromosomal translocation that involves the chromosomes 4 and 14.
National Institutes of Health

Related topics

Related topics

2 relations
Chromosomes, Human, Pair 14Chromosomes, Human, Pair 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Current and New Therapeutic Strategies for Relapsed and Refractory Multiple Myeloma: An Update
Although survival of multiple myeloma patients has at least doubled during recent years, most patients eventually relapse, and… 
Highly Cited
2013
Highly Cited
2013
Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load.
PURPOSE The aim of this study was to analyze chromosomal aberrations in terms of frequency and impact on time to progression in… 
Highly Cited
2013
Highly Cited
2013
Multiple myeloma: 2013 update on diagnosis, risk‐stratification, and management
Multiple myeloma accounts for approximately 10% of hematologic malignancies. 
Review
2012
Review
2012
Multiple myeloma: 2012 update on diagnosis, risk‐stratification, and management
Disease overview: Multiple myeloma accounts for ∼10% of all hematologic malignancies. 
Highly Cited
2009
Highly Cited
2009
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells
The t(4;14) translocation leads to the simultaneous overexpression of two genes, FGFR3 and MMSET, in myeloma plasma cells. The… 
Highly Cited
2007
Highly Cited
2007
Clinical significance of TP53 mutation in myeloma
Highly Cited
2006
Highly Cited
2006
The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells.
The association of fibroblast growth factor receptor 3 (FGFR3) expression with t(4;14) multiple myeloma (MM) and the… 
Highly Cited
2003
Highly Cited
2003
In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression.
This study analyzed the frequency and clinical significance of t(4;14)(p16;q32) in multiple myeloma (MM) among 208 patients with… 
Highly Cited
2002
Highly Cited
2002
Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation.
Multiple myeloma (MM) is a plasma-cell malignancy characterized by marked epidemiological, biological, and clinical heterogeneity… 
Highly Cited
2002
Highly Cited
2002
Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy.
Recently, we have described the biological correlations associated with the main translocations involving the 14q32 chromosomal… 
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