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t(12;21)

A cytogenetic abnormality that involves a translocation between chromosomes 12 and 21.
National Institutes of Health

Related topics

Related topics

2 relations
Chromosomes, Human, Pair 12Chromosomes, Human, Pair 21

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Differential miRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features.
Review
2006
Review
2006
Chromatin structural elements and chromosomal translocations in leukemia.
Highly Cited
2006
Highly Cited
2006
CoXpress: differential co-expression in gene expression data
BackgroundTraditional methods of analysing gene expression data often include a statistical test to find differentially expressed… 
Highly Cited
2006
Highly Cited
2006
CpG Island Methylator Phenotype Redefines the Prognostic Effect of t(12;21) in Childhood Acute Lymphoblastic Leukemia
Purpose: To examine cancer genes undergoing epigenetic inactivation in a set of ETV6/RUNX1-positive acute lymphoblastic leukemias… 
Highly Cited
2003
Highly Cited
2003
Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable
Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable 
Review
2001
Review
2001
Flow cytometry in the diagnosis of acute leukemia.
Highly Cited
1999
Highly Cited
1999
Rapid and sensitive minimal residual disease detection in acute leukemia by quantitative real‐time RT‐PCR exemplified by t(12;21) TEL‐AML1 fusion transcript
Because previous PCR‐based methodologies for detection of minimal residual disease (MRD) in leukemia patients have been too… 
Highly Cited
1999
Highly Cited
1999
Cytogenetic abnormalities associated with the t(12;21): a collaborative study of 169 children with t(12;21)-positive acute lymphoblastic leukemia
The t(12;21)(p13;q22) is a cryptic abnormality observed in 25% of children with B-lineage acute lymphoblastic leukemia (ALL… 
Highly Cited
1999
Highly Cited
1999
Both TEL and AML-1 Contribute Repression Domains to the t(12;21) Fusion Protein
ABSTRACT t(12;21) is the most frequent translocation found in pediatric B-cell acute lymphoblastic leukemias. This translocation… 
Highly Cited
1997
Highly Cited
1997
ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia
The presence of ETV6 deletions was investigated in 215 children with acute lymphoblastic leukemia (ALL) using the loss of… 
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