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Chromosomes, Human, Pair 21

Known as: 21 chromosome, Chromosome 21 
The designation for each member of the second smallest human autosomal chromosome pair. Chromosome 21 spans around 47 million nucleotides and… 
National Institutes of Health

Related topics

Related topics

19 relations
21qANKRD30BP1 geneChromatinChromosome 21 Short Arm

Narrower (2)

Chromosome 21, tetrasomy 21qHypotonia-Cystinuria Syndrome

Broader (2)

ChromosomesChromosomes, Human, 21-22 and Y

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Rare Copy Number Variants in Isolated Sporadic and Syndromic Atrioventricular Septal Defects
Atrioventricular septal defects (AVSDs) are a frequent but not universal component of Down syndrome (DS), while AVSDs in… 
Highly Cited
1999
Highly Cited
1999
Trisomy 21 is a recurrent secondary aberration in childhood acute lymphoblastic leukemia with TEL/AML1 gene fusion
TEL/AML1 gene fusion is the most frequent genetic lesion in pediatric acute lymphoblastic leukemia (ALL). It occurs as a… 
Review
1998
Review
1998
Analysis of TEL proteins in human leukemias
Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion… 
1995
1995
Localization of 102 exons to a 2.5 Mb region involved in Down syndrome.
Exon amplification has been applied to a 2.5 Mb region of chromosome 21 that has been associated with some features of Down… 
Review
1994
Review
1994
Separation anxiety: the etiology of nondisjunction in flies and people.
Two new studies examine the recombinational history of human chromosomes that nondisjoin at the first meiotic division in females… 
1993
1993
A chromosome 13-specific human satellite I DNA subfamily with minor presence on chromosome 21: further studies on Robertsonian translocations.
We describe a new human satellite I DNA subfamily (pTRI-6) which is composed of 72 copies of monomeric repeating units of 42… 
Highly Cited
1992
Highly Cited
1992
Linkage studies in progressive myoclonus epilepsy
The progressive myoclonus epilepsies (PME) are a heterogeneous group of rare genetic disorders. Unverricht-Lundborg disease and… 
Highly Cited
1986
Highly Cited
1986
Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.
We have used a panel of Chinese hamster X human somatic cell hybrids, each containing various portions of chromosome 21 as the… 
Highly Cited
1985
Highly Cited
1985
Cloned DNA probes regionally mapped to human chromosome 21 and their use in determining the origin of nondisjunction.
A number of unique sequence recombinant DNA clones were isolated from a recombinant DNA library constructed from DNA enriched for… 
Highly Cited
1978
Highly Cited
1978
Presence of human chromosome 21 alone is sufficient for hybrid cell sensitivity to human interferon
Human/mouse somatic cell hybrids with chromosome 21 as the only detectable human genetic material were sensitive to both human… 
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