Chromosomes, Human, Pair 21

Known as: 21 chromosome, Chromosome 21 
The designation for each member of the second smallest human autosomal chromosome pair. Chromosome 21 spans around 47 million nucleotides and… (More)
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
Homologous sets of transcription factors direct conserved tissue-specific gene expression, yet transcription factor-binding… (More)
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Highly Cited
2008
Highly Cited
2008
Down syndrome (DS), or Trisomy 21, is the most common genetic cause of cognitive impairment and congenital heart defects in the… (More)
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Highly Cited
2007
Highly Cited
2007
Down syndrome caused by chromosome 21 trisomy is the most common genetic cause of mental retardation in humans. Disruption of the… (More)
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Review
2004
Review
2004
The sequence of chromosome 21 was a turning point for the understanding of Down syndrome. Comparative genomics is beginning to… (More)
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Highly Cited
2002
Highly Cited
2002
The use of comparative genomics to infer genome function relies on the understanding of how different components of the genome… (More)
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Highly Cited
2001
Highly Cited
2001
Global patterns of human DNA sequence variation (haplotypes) defined by common single nucleotide polymorphisms (SNPs) have… (More)
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Highly Cited
2000
Highly Cited
2000
Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic… (More)
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Highly Cited
1996
Highly Cited
1996
The cause of non–disjunction of chromosome 21 remains largely unknown. Advanced maternal age is associated with both maternal… (More)
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Highly Cited
1991
Highly Cited
1991
A LOCUS segregating with familial Alzheimer's disease (AD) has been mapped to chromosome 21 (ref. 1), close to the amyloid… (More)
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Highly Cited
1987
Highly Cited
1987
Alzheimer's disease1 is characterized by a widespread functional disturbance of the human brain. Fibrillar amyloid proteins are… (More)
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