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t(8;21)

A cytogenetic abnormality that involves a translocation between chromosomes 8 and 21.
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
Diagnostic karyotype provides the framework for risk-stratification schemes in acute myeloid leukemia (AML); however, the… Expand
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Highly Cited
2006
Highly Cited
2006
PURPOSE To analyze the prognostic impact of mutated KIT (mutKIT) in core-binding factor acute myeloid leukemia (AML) with inv(16… Expand
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Highly Cited
2002
Highly Cited
2002
The AML1/CBFbeta transcription factor complex, a frequent target of chromosomal translocations in leukemia, is essential for the… Expand
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Highly Cited
2001
Highly Cited
2001
The transcription factor CCAAT/enhancer binding protein α, or C/EBPα, encoded by the CEBPA gene, is crucial for the… Expand
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Highly Cited
2000
Highly Cited
2000
Leukemia-specific AML1/ETO transcripts are detectable in most patients with t(8;21) acute myelogenous leukemia (AML) in long-term… Expand
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Highly Cited
1998
Highly Cited
1998
ABSTRACT t(8;21) is one of the most frequent translocations associated with acute myeloid leukemia. It produces a chimeric… Expand
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Highly Cited
1998
Highly Cited
1998
Cytogenetics is considered one of the most valuable prognostic determinants in acute myeloid leukemia (AML). However, many… Expand
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Highly Cited
1998
Highly Cited
1998
The t(8;21) translocation between two genes known as AML1 and ETO is seen in approximately 12-15% of all acute myeloid leukemia… Expand
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Highly Cited
1992
Highly Cited
1992
We have developed a restriction map of the chromosome 21 breakpoint region involved in t(8;21)(q22;q22.3) acute myelogenous… Expand
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Highly Cited
1991
Highly Cited
1991
The t(8;21)(q22;q22) translocation is a non-random chromosomal abnormality frequently found in patients with acute myeloid… Expand
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