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t(8;21)

A cytogenetic abnormality that involves a translocation between chromosomes 8 and 21.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Methylation-associated silencing of BASP1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia
The AML1-ETO fusion protein (A/E), which results from the t(8;21) translocation, is considered to be a leukemia-initiating event… 
2009
2009
Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less advanced disease phase and does not increase SCT Toxicity in patients with…
Prior treatment with the tyrosine kinase inhibitors dasatinib and nilotinib allows stem cell transplantation (SCT) in a less… 
Highly Cited
2008
Highly Cited
2008
Transcriptional repression of the RUNX3/AML2 gene by the t(8;21) and inv(16) fusion proteins in acute myeloid leukemia.
RUNX3/AML2 is a Runt domain transcription factor like RUNX1/AML1 and RUNX2/AML3. Regulated by 2 promoters P1 and P2, RUNX3 is… 
Highly Cited
2007
Highly Cited
2007
Association between prenatal pesticide exposures and the generation of leukemia‐associated T(8;21)
This study was designed to investigate the relationship between prenatal pesticide exposures and the generation of leukemia… 
2006
2006
Association of the heterozygous germline I171V mutation of the NBS1 gene with childhood acute lymphoblastic leukemia
Association of the heterozygous germline I171V mutation of the NBS1 gene with childhood acute lymphoblastic leukemia 
Highly Cited
2005
Highly Cited
2005
The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor
The human translocation (t8;21) is associated with ∼12% of the cases of acute myelogenous leukemia. Two genes, AML1 and ETO, are… 
2000
2000
Good outcome of children with acute myeloid leukemia and t(8;21)(q22;q22), even when associated with granulocytic sarcoma
The association between t(8;21) and granulocytic sarcoma (GS) is well known, but to the authors' knowledge the prognostic… 
Highly Cited
1996
Highly Cited
1996
ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease.
To study acute myelogenous leukemia 1 (AML1) transcription factor, ETO protein, and t(8;21) AML chimeric AML1/ ETO protein in… 
1985
1985
The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia.
The human c-mos proto-oncogene is located on chromosome 8 at band q22, close to the breakpoint in the t(8;21) (q22;q22… 
Highly Cited
1983
Highly Cited
1983
Cytological types of mitoses and chromosome abnormalities in acute leukemia.
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