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Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
In vivo and in vitro evidence is provided that r4 expression involves direct autoregulation dependent on cooperative interactions of Hoxb-1 with exd/pbx proteins as cofactors. Expand
The role of DNA shape in protein-DNA recognition
These findings indicate that the ability to detect local variations in DNA shape and electrostatic potential is a general mechanism that enables proteins to use information in the minor groove, which otherwise offers few opportunities for the formation of base-specific hydrogen bonds, to achieve DNA-binding specificity. Expand
Nuclear Translocation of Extradenticle Requires homothorax , which Encodes an Extradenticle-Related Homeodomain Protein
A novel and evolutionarily conserved mechanism for regulating HOX activity in which a direct protein-protein interaction between EXD and HTH results in EXD's nuclear translocation is suggested. Expand
Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt.
- J. Bessa, B. Gebelein, F. Pichaud, F. Casares, R. Mann
- Biology, Medicine
- Genes & development
- 15 September 2002
Evidence is provided that this combination of transcription factors may function as a complex and that it plays at least two roles in eye development: it blocks the expression of later-acting transcription factors in the eye development cascade, and it promotes cell proliferation. Expand
Origins of specificity in protein-DNA recognition.
- R. Rohs, Xiangshu Jin, S. West, R. Joshi, B. Honig, R. Mann
- Biology, Medicine
- Annual review of biochemistry
- 9 June 2010
This review provides a revised view of protein-DNA interactions that emphasizes the importance of the three-dimensional structures of both macromolecules and argues that individual DNA-binding proteins combine multiple readout mechanisms to achieve DNA- binding specificity. Expand
Hox specificity unique roles for cofactors and collaborators.
Together, these analyses reveal an enormous amount of flexibility into how Hox proteins function to regulate gene expression, perhaps providing an explanation for why these factors have been central players in the evolution of morphological diversity in the animal kingdom. Expand
Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.
It is shown that a conserved N-terminal domain of HTH directly binds to EXD in vitro, and is sufficient to induce the nuclear localization ofEXD in vivo, however, mutating a key DNA binding residue in the HTH homeodomain abolishes many of its in vivo functions. Expand
The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
Cooperative interactions between Ubx protein and a divergent homeodomain protein, extradenticle (exd), that selectively increases the affinity of Ubx, but not Antp, for a particular DNA target are described. Expand
Control of antennal versus leg development in Drosophila
Four lines of evidence are presented that identify extradenticle (exd) and homothorax (hth) as antennal-determining genes and that Antp promotes leg development by repressing hth and consequently nuclear Exd. Expand
Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins
An experimental and computational platform that can be used to determine the relative affinities to any DNA sequence for any transcription factor complex is developed, and it is shown that Drosophila Hox proteins obtain novel recognition properties when they bind DNA with the dimeric cofactor Extradenticle-Homothorax. Expand