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t(2;13)

A cytogenetic abnormality that involves a translocation between chromosomes 2 and 13.
National Institutes of Health

Related topics

Related topics

2 relations
Chromosomes, Human, Pair 13Chromosomes, Human, Pair 2

Papers overview

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Highly Cited
2006
Highly Cited
2006
Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas.
Alveolar rhabdomyosarcomas (ARMS) are aggressive soft-tissue sarcomas affecting children and young adults. Most ARMS tumors… 
Review
2001
Review
2001
Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma
  • F. Barr
  • Oncogene
  • 2001
  • Corpus ID: 9593620
The chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) are characteristic of alveolar rhabdomyosarcoma, a pediatric… 
Highly Cited
1999
Highly Cited
1999
Negative Regulation of the Forkhead Transcription Factor FKHR by Akt*
The FKHR gene was first identified from its disruption by the t(2;13) chromosomal translocation seen in the pediatric tumor… 
Highly Cited
1998
Highly Cited
1998
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
Alveolar rhabdomyosarcomas are associated with unique chromosomal translocations t(2;13) and t(1;13), which arise from fusion of… 
Highly Cited
1996
Highly Cited
1996
Pax3 modulates expression of the c-Met receptor during limb muscle development.
Pax3 is a transcription factor whose expression has been used as a marker of myogenic precursor cells arising in the lateral… 
Highly Cited
1995
Highly Cited
1995
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and… 
Highly Cited
1994
Highly Cited
1994
Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.
Although the t(2;13)(q35;q14) translocation has been found in most cases of the pediatric cancer alveolar rhabdomyosarcoma… 
Highly Cited
1994
Highly Cited
1994
Solid Alveolar Rhabdomyosarcomas with the t(2;13): Report of Two Cases with Diagnostic Implications
Two patients having rhabdomyosarcomas with the recently described “solid variant” pattern of alveolar rhabdomyosarcoma are… 
Highly Cited
1993
Highly Cited
1993
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma
We have examined the structure and expression of the products associated with the t(2;13)(q35;q14) translocation associated with… 
Highly Cited
1993
Highly Cited
1993
Alveolar rhabdomyosarcoma with the t(2;13): cytogenetic findings and clinicopathologic correlations.
We describe here the clinical and pathologic features associated with a specific translocation, t(2;13), in alveolar… 
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