t(12;21)

A cytogenetic abnormality that involves a translocation between chromosomes 12 and 21.
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
The t(12;21) translocation, which generates the TEL-AML1 (ETV6-RUNX1) fusion gene, is the most common structural chromosome… (More)
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Highly Cited
2002
Highly Cited
2002
TEL-AML1 is expressed from the t(12;21) chromosomal translocation inB-precursor acute lymphocytic leukemia (ALL). Creation of the… (More)
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Highly Cited
1999
Highly Cited
1999
t(12;21) is the most frequent translocation found in pediatric B-cell acute lymphoblastic leukemias. This translocation fuses a… (More)
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Review
1999
Review
1999
Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia patients have shown that large-scale MRD… (More)
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Highly Cited
1996
Highly Cited
1996
The t(12;21) translocation is present in up to 30% of childhood B-cell acute lymphoblastic and fuses a potential dimerization… (More)
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Highly Cited
1996
Highly Cited
1996
A recurrent t(12;21)(p13;q22) has recently been described in human acute lymphoblastic leukemias (ALLs). This translocation fuses… (More)
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Highly Cited
1995
Highly Cited
1995
The t(12;21)(p13;q22) is identified by routine cytogenetics in less than 0.05% of pediatric acute lymphoblastic leukemia (ALL… (More)
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Highly Cited
1995
Highly Cited
1995
The recurrent t(12;21)(p12;q22) translocation fuses two genes, TEL and AML1, that have previously been shown to be independently… (More)
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Highly Cited
1995
Highly Cited
1995
Analysis of a growing number of chromosomal translocations in human tumors have shown that they frequently result in gene fusions… (More)
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Highly Cited
1994
Highly Cited
1994
A t(12;21)(p11-p12;q22) was detected by chromosome painting in three patients with acute lymphoblastic leukemia (ALL) among eight… (More)
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