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t(12;21)

A cytogenetic abnormality that involves a translocation between chromosomes 12 and 21.
National Institutes of Health

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2 relations
Chromosomes, Human, Pair 12Chromosomes, Human, Pair 21

Papers overview

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2004
2004
TEL/AML1 shows dominant-negative effects over TEL as well as AML1.
2003
2003
Complex karyotypes in childhood acute lymphoblastic leukemia: cytogenetic and molecular cytogenetic study of 21 cases.
Highly Cited
2003
Highly Cited
2003
Small ubiquitin-like modifier conjugation regulates nuclear export of TEL, a putative tumor suppressor
Posttranslational modification by small ubiquitin-like modifier (SUMO) conjugation regulates the subnuclear localization of… 
2002
2002
High incidence of Hox11L2 expression in children with T-ALL
The orphan homeobox gene HOX11L2 was previously found to be transcriptionally activated as a result of the t(5;14)(q35;q32… 
1998
1998
High frequency of t(12;21) in childhood acute lymphoblastic leukemia detected by RT‐PCR
Summary Recently, a new recurrent translocation, t(12;21)(p13;q22), has been identified in B‐cell lineage acute lymphoblastic… 
1997
1997
Low frequency of TEL/AML1 in adult acute lymphoblastic leukemia.
Highly Cited
1996
Highly Cited
1996
The der(21)t(12;21) chromosome is always formed in a 12;21 translocation associated with childhood acute lymphoblastic leukaemia
We studied 116 patients (93 children and 23 adults) with acute lymphoblastic leukaemia (ALL) using fluorescence in situ… 
Review
1996
Review
1996
Molecular cytogenetics of t(12;21) (p13;q22).
The translocation t(12;21)(p13;q22) is a frequent nonrandom rearrangement of B-cell lineage childhood acute lymphoblastic… 
Highly Cited
1996
Highly Cited
1996
High incidence of TEL/AML1 fusion resulting from a cryptic t(12;21) in childhood B-lineage acute lymphoblastic leukemia in Taiwan.
Despite its rarity by routine karyotypic analysis, cryptic t(12;21)(p12-13;q22) translocation leading to TEL/AML1 fusion has been… 
1978
1978
Trisomy 12p syndrome Evaluation of a family with a t(12;21)(p12.1;p11) translocation with unbalanced offspring
Two brothers (Nos. 1 and 3), with physical and mental retardation and many other clinical characteristics in common, were both… 
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