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t(2;13)

A cytogenetic abnormality that involves a translocation between chromosomes 2 and 13.
National Institutes of Health

Related topics

Related topics

2 relations
Chromosomes, Human, Pair 13Chromosomes, Human, Pair 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Future directions in risk stratification and therapy for advanced pediatric genitourinary rhabdomyosarcoma.
Highly Cited
2006
Highly Cited
2006
Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas.
Alveolar rhabdomyosarcomas (ARMS) are aggressive soft-tissue sarcomas affecting children and young adults. Most ARMS tumors… 
Review
2001
Review
2001
Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma
The chromosomal translocations t(2;13)(q35;q14) and t(1;13)(p36;q14) are characteristic of alveolar rhabdomyosarcoma, a pediatric… 
Highly Cited
1996
Highly Cited
1996
Pax3 modulates expression of the c-Met receptor during limb muscle development.
Pax3 is a transcription factor whose expression has been used as a marker of myogenic precursor cells arising in the lateral… 
Highly Cited
1995
Highly Cited
1995
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
Alveolar rhabdomyosarcomas are pediatric solid tumors with a hallmark cytogenetic abnormality: translocation of chromosomes 2 and… 
Highly Cited
1995
Highly Cited
1995
Pax3 Inhibits Myogenic Differentiation of Cultured Myoblast Cells (*)
Pax3 is an evolutionarily conserved transcription factor expressed in the lateral dermomyotome, a region that gives rise to limb… 
Highly Cited
1995
Highly Cited
1995
Detection of the t(2;13)(q35;q14) and PAX3‐FKHR fusion in alveolar rhabdomyosarcoma by fluorescence in situ hybridization
Cytogenetic studies of the pediatric solid tumor alveolar rhabdomyosarcoma have demonstrated the presence of a consistent… 
Highly Cited
1994
Highly Cited
1994
Solid Alveolar Rhabdomyosarcomas with the t(2;13): Report of Two Cases with Diagnostic Implications
Two patients having rhabdomyosarcomas with the recently described “solid variant” pattern of alveolar rhabdomyosarcoma are… 
Highly Cited
1993
Highly Cited
1993
Alveolar rhabdomyosarcoma with the t(2;13): cytogenetic findings and clinicopathologic correlations.
We describe here the clinical and pathologic features associated with a specific translocation, t(2;13), in alveolar… 
Highly Cited
1987
Highly Cited
1987
A specific chromosomal abnormality in rhabdomyosarcoma.
A specific chromosomal abnormality, t(2;13)(q35;q14), was discovered in five cases of advanced rhabdomyosarcoma. It was… 
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