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Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
Two niches with distinct characteristics work in tandem. Intestinal epithelial stem cell identity and location have been the subject of substantial research. Cells in the +4 niche are slow-cyclingExpand
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Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.
Transcription factor-based cellular reprogramming has opened the way to converting somatic cells to a pluripotent state, but has faced limitations resulting from the requirement for transcriptionExpand
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TBX1 Is Responsible for Cardiovascular Defects in Velo-Cardio-Facial/DiGeorge Syndrome
Velo-cardio-facial syndrome (VCFS)/DiGeorge syndrome (DGS) is a human disorder characterized by a number of phenotypic features including cardiovascular defects. Most VCFS/DGS patients are hemizygousExpand
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Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives.
Pax3 is a transcription factor expressed in the dorsal neural tube and somite of the developing embryo. It plays critical roles in pre-migratory neural crest cells and in myogenic precursors ofExpand
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Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes.
Pax genes encode a family of developmentally regulated transcription factors that have been implicated in a number of human and murine congenital disorders, as well as in tumorigenesis (Gruss, P.,Expand
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Two independent and interactive DNA-binding subdomains of the Pax6 paired domain are regulated by alternative splicing.
Vertebrate Pax proteins share a conserved 128-amino-acid DNA-binding motif, the paired domain. The PAX6 gene, which is mutated in the murine Small eye and human aniridia developmental defects, alsoExpand
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Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations.Expand
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Pax3 functions at a nodal point in melanocyte stem cell differentiation
Most stem cells are not totipotent. Instead, they are partially committed but remain undifferentiated. Upon appropriate stimulation they are capable of regenerating mature cell types. Little is knownExpand
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Getting your Pax straight: Pax proteins in development and disease.
The Pax gene family encodes a group of transcription factors that have been conserved through millions of years of evolution and play roles in early development. Pax proteins have been implicated asExpand
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PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development.
The identification of new signaling pathways critical for cardiac morphogenesis will contribute to our understanding of congenital heart disease (CHD), which remains a leading cause of mortality inExpand
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