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ABSTRACT Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a growing concern due to… Expand The in vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates of Escherichia… Expand This Account describes the use of molecular dynamics (MD) simulations to reveal how mutations alter the structure and… Expand Significance Ketoreductases are the most commonly used enzymes in industrial pharmaceutical synthesis. We investigated the nature… Expand Natural and man-made organosulfur compounds play important roles in biological and medicinal chemistry. Among the various classes… Expand ABSTRACT Agar dilution MIC methodology was used to compare the activity of sulopenem with those of amoxicillin/clavulanate… Expand ABSTRACT Clinical isolates of Klebsiella pneumoniae resistant to carbapenems and essentially all other antibiotics (multidrug… Expand ABSTRACT Acinetobacter spp. are emerging as opportunistic hospital pathogens that demonstrate resistance to many classes of… Expand Many β‐lactam antimicrobials were developed between the 1960s and 1980s, with continuing development driven by the emergence of… Expand ABSTRACT Pseudomonas aeruginosa exhibits high intrinsic resistance to penem antibiotics such as faropenem, ritipenem, AMA3176… Expand