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src Oncogene

Known as: v-src Oncogenes, Oncogene SRC, Gene, v-src 
A retroviral DNA or mutated host gene that encodes a hyperactive form of the proto-oncogene tyrosine-protein kinase Src protein. This oncogene is… 
National Institutes of Health

Related topics

Related topics

8 relations
20q12-q13Homo sapiensNeoplastic Cell TransformationProtein phosphorylation

Broader (1)

Genes, src

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Transcription of the bone sialoprotein gene is stimulated by v-Src acting through an inverted CCAAT box.
Bone sialoprotein (BSP) is an early marker of differentiated osteoblasts that has been implicated in the nucleation of… 
Highly Cited
1998
Highly Cited
1998
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways.
The integrin-linked kinase (ILK) is an ankyrin repeat containing serine-threonine protein kinase that can interact directly with… 
Highly Cited
1997
Highly Cited
1997
Insulin-like growth factor I receptor signaling in transformation by src oncogenes
R- cells, a line of mouse embryo fibroblasts with a targeted disruption of the insulin-like growth factor I (IGF-I) receptor… 
Highly Cited
1997
Highly Cited
1997
Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs
The v-src oncogene encodes a nonreceptor tyrosine kinase. When this gene was expressed in the myeloblastic cell line 32Dcl3, it… 
Highly Cited
1995
Highly Cited
1995
v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor (*)
A consensus cyclic AMP response element (CRE) in the murine prostaglandin synthase-2 (PGS2) promoter is essential for pgs2 gene… 
Highly Cited
1994
Highly Cited
1994
v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element
We recently reported the cloning of a mitogen-inducible prostaglandin synthase gene, TIS10/PGS2. In addition to growth factors… 
Highly Cited
1992
Highly Cited
1992
Ornithine decarboxylase activity is critical for cell transformation
THE enzyme ornithine decarboxylase is the key regulator of the synthesis of polyamines1–3 which are essential for cell… 
Highly Cited
1990
Highly Cited
1990
Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.
The ras gene product (p21) is a GTP-binding protein and has been thought to transduce signals regulating proliferation or… 
Highly Cited
1988
Highly Cited
1988
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant
The transforming protein of Rous sarcoma virus, pp60v-src, is covalently coupled to myristic acid by an amide linkage to glycine… 
Highly Cited
1986
Highly Cited
1986
Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl, and src oncogenes
In vitro infection of bone marrow or fetal liver cells with retroviruses containing fes, abl, ras, or src oncogenes resulted in… 
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