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R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.
TLDR
The developmental control of the four key elements of R8 development: selection, spacing, differentiation and orchestration of later events are discussed. Expand
Eyes absent represents a class of protein tyrosine phosphatases
TLDR
Eyes absent is the prototype for a class of protein tyrosine phosphatases that use a nucleophilic aspartic acid in a metal-dependent reaction and contributes to its ability to induce eye formation in Drosophila. Expand
senseless Repression of rough Is Required for R8 Photoreceptor Differentiation in the Developing Drosophila Eye
TLDR
Surprisingly, there is no loss of ommatidial clusters in senseless mutant tissue and all outer photoreceptor subtypes can be recruited, suggesting that other photoreceptors can substitute for R8 to initiate recruitment and that R8-specific signaling is not required for outer photOREceptor subtype assignment. Expand
Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras
TLDR
The identified cDNAs, 322, represent a novel src- and ras-regulated gene which encodes a potential regulator of mitogenesis and/or tumor suppressor. Expand
Senseless is required for pupal retinal development in Drosophila
TLDR
The function of senseless is analyzed during pupal retinal development and it is found that senseless is required for recruitment of both cone and pigment cells, the pupal‐derived ommatidial support cells, and is both necessary and sufficient for interommatidials bristle development. Expand
Regulation of R7 and R8 differentiation by the spalt genes.
TLDR
It is suggested that while spalt is required for R7 differentiation during larval stages, spalt and senseless promote terminal R8 differentiation during pupal stages, including the regulation of rhodopsin expression. Expand
Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate
TLDR
New evidence is provided that lateral inhibition, but not ro, is required for the initial selection of a single R8 precursor, and results support a new model for R8 selection in which lateral inhibition establishes a transient pattern of selected R8s that is permanently reinforced by a repressive bistable loop between sens and ro. Expand
Elevated intraocular pressure causes inner retinal dysfunction before cell loss in a mouse model of experimental glaucoma.
TLDR
Polystyrene bead injection results in a mild, chronic elevation of IOP that recapitulates several critical aspects of human ocular hypertension and glaucoma, and results in early changes in retinal electrical function that precede histologic changes. Expand
Senseless represses nuclear transduction of Egfr pathway activation
TLDR
It is shown that high levels of Egfr activation are incompatible with R8 differentiation and the mechanism by which Egfr signaling is actively prevented in R8 is described, which promotes normal R 8 differentiation by preventing the effects of autocrine stimulation by Spitz. Expand
Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice
TLDR
The finding that elevated IOP alters neuronal function in the inner retina before irreversible structural damage occurs provides useful information for developing new diagnostic tools and treatments for glaucoma in human patients. Expand
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