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spiromustine

Known as: 1,3-Diazaspiro(4.5)decane-2,4-dione, 3-(2-(bis(2-chloroethyl)amino)ethyl)-, Spirohydantoin Mustard, SHM 
A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

HydantoinsNitrogen Mustard Compounds
NCIt Antineoplastic Agent Terminology

Narrower (1)

NSC 172112

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2014 Updates.
Review
2010
Review
2010
Mechanisms of chromosomal rearrangement in the human genome
Many human cancers are associated with characteristic chromosomal rearrangements, especially hematopoietic cancers such as… 
Highly Cited
2008
Highly Cited
2008
Broadening of Neutralization Activity to Directly Block a Dominant Antibody-Driven SARS-Coronavirus Evolution Pathway
Phylogenetic analyses have provided strong evidence that amino acid changes in spike (S) protein of animal and human SARS… 
Highly Cited
2007
Highly Cited
2007
Geometrical optimization of helical flow in grooved micromixers.
Owing to the enhancement of surface effects at the micro-scale, patterned grooves on a micro-channel floor remain a powerful… 
Highly Cited
2006
Highly Cited
2006
Distributed computing strategy for structural health monitoring
Monitoring of complex structures to provide real‐time safety and reliability information regarding the structure poses… 
Highly Cited
2006
Highly Cited
2006
Crocidolite asbestos and SV40 are cocarcinogens in human mesothelial cells and in causing mesothelioma in hamsters.
Highly Cited
2005
Highly Cited
2005
Familial basilar migraine associated with a new mutation in the ATP1A2 gene
Basilar migraine (BM), familial hemiplegic migraine (FHM), and sporadic hemiplegic migraine (SHM) are phenotypically similar… 
Highly Cited
2004
Highly Cited
2004
Modeling of piezoelectric-based Lamb wave generation and sensing for structural health monitoring
Among the various schemes being considered for Structural Health Monitoring (SHM), Lamb-wave testing has shown great promise… 
Highly Cited
2004
Highly Cited
2004
The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process.
The overexpanded clone in most B-cell-type chronic lymphocytic leukemia (BCLL) patients expresses an immunoglobulin (Ig) heavy… 
Highly Cited
2003
Highly Cited
2003
Msh2 ATPase Activity Is Essential for Somatic Hypermutation at A-T Basepairs and for Efficient Class Switch Recombination
Somatic hypermutation (SHM) and class switch recombination (CSR) are initiated by activation-induced cytidine deaminase–mediated… 
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