sphingosine phosphorylcholine

Known as: Ethanaminium, 2-((((2-amino-3-hydroxy-4-octadecenyl)oxy)hydroxyphosphinyl)oxy)-N,N,N-trimethyl-, chloride, (R-(R*,S*-(E)))-, sphingosylphosphorylcholine, sphingosylphosphocholine 
 
National Institutes of Health

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3 relations

Broader (2)

PhosphorylcholineSphingosine
analogs & derivatives

Papers overview

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Review
2007
Review
2007
Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism.
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC) and… (More)
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Highly Cited
2006
Highly Cited
2006
Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism.
Mesenchymal stem cells (MSCs) can differentiate into diverse cell types including adipogenic, osteogenic, chondrogenic and… (More)
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Review
2005
Review
2005
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.
We investigate connections between single-cell mechanical properties and subcellular structural reorganization from biochemical… (More)
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Highly Cited
2004
Highly Cited
2004
HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3.
HDL is a major atheroprotective factor, but the mechanisms underlying this effect are still obscure. HDL binding to scavenger… (More)
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Highly Cited
2003
Highly Cited
2003
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive lipid that is present in high density lipoproteins (HDL… (More)
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Highly Cited
2001
Highly Cited
2001
Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids.
Apoptotic cell death following injury of vascular endothelium is assumed to play an important role in the pathogenesis of… (More)
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Highly Cited
1999
Highly Cited
1999
Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.
Sphingosine 1-phosphate (S1P) is one of several bioactive phospholipids that exert profound mitogenic and morphogenic actions… (More)
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Highly Cited
1998
Highly Cited
1998
Lysenin, a novel sphingomyelin-specific binding protein.
Lysenin, a novel 41-kDa protein purified from coelomic fluid of the earthworm Eisenia foetida, induced erythrocyte lysis… (More)
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Highly Cited
1998
Highly Cited
1998
EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein…
In Chinese hamster ovary (CHO) cells transiently transfected with an expression vector for EDG1, but not an empty vector… (More)
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Highly Cited
1997
Highly Cited
1997
Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids.
The structural similarity of lysosphingolipids to lysophosphatidic acid (LPA) prompted a sequence-based search for… (More)
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