sofosbuvir

Known as: Sofosbuvir [Chemical/Ingredient], L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl Ester, 2-((5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy)phenoxyphosphorylamino)propionic acid isopropyl ester 
An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2017
020040019922017

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND In phase 2 trials, treatment with the combination of the nucleotide polymerase inhibitor sofosbuvir and the NS5A… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained… (More)
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Highly Cited
2014
Highly Cited
2014
INTRODUCTION Hepatitis C virus (HCV) infection in end stage renal disease (ESRD) is associated with increased mortality. Recently… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND High rates of sustained virologic response were observed among patients with hepatitis C virus (HCV) infection who… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND All-oral combination therapy is desirable for patients with chronic hepatitis C virus (HCV) infection. We evaluated… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND In clinical trials, treatment with a combination of the nucleotide polymerase inhibitor sofosbuvir and the antiviral… (More)
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Highly Cited
2014
Highly Cited
2013
Highly Cited
2013
BACKGROUND In phase 2 trials, the nucleotide polymerase inhibitor sofosbuvir was effective in previously untreated patients with… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Patients chronically infected with hepatitis C virus (HCV) genotype 2 or 3 for whom treatment with peginterferon is… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND The standard treatment for hepatitis C virus (HCV) infection is interferon, which is administered subcutaneously and… (More)
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