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Statements from the Taormina expert meeting on occult hepatitis B virus infection.
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Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes
TLDR
These proposals provide the framework by which the HCV databases store and provide access to data on HCV, which will internationally coordinate the assignment of new genotypes and subtypes in the future.
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Telaprevir and peginterferon with or without ribavirin for chronic HCV infection.
TLDR
In this phase 2 study of patients infected with HCV genotype 1 who had not been treated previously, one of the three telaprevir groups had a significantly higher rate of sustained virologic response than that with standard therapy.
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An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection…
TLDR
It is demonstrated that infection of hepatocarcinoma cells by HCVpp is increased more than 10-fold by human serum factors, of which high-density lipoprotein (HDL) is a major component, and HVR1 new roles which are complementary in helping HCV to survive within its host.
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Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens.
TLDR
First-line treatment strategies should be optimized to efficiently prevent treatment failure due to HCV resistance, as viral variants resistant to NS5A inhibitors at baseline is associated with lower rates of virological cure in certain groups of patients.
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Antiviral drug‐resistant HBV: Standardization of nomenclature and assays and recommendations for management
TLDR
There is a need to standardize nomenclature relating to hepatitis B antiviral resistance, and to define genotypic, phenotypesic, and clinical resistance to NA therapy.
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Structural biology of hepatitis C virus
TLDR
Structural analyses of HCV components provide an essential framework for understanding of the molecular mechanisms ofHCV polyprotein processing, RNA replication, and virion assembly and may contribute to a betterUnderstanding of the pathogenesis of hepatitis C.
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Structural biology of hepatitis C virus.
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EASL Recommendations on Treatment of Hepatitis C 2016.
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Treatment failure and resistance with direct‐acting antiviral drugs against hepatitis C virus
Current treatment of chronic hepatitis C virus (HCV) infection is based on the combination of pegylated interferon‐α and ribavirin. The recent development of direct‐acting antiviral (DAA) molecules…
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