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“The general aim of this series of papers is to determine the laws which govern movements of ions during electrical activity.” So… Expand This review summarizes data in support of the notion that the cardiac intercalated disc is the host of a protein interacting… Expand Mutations in proteins of the desmosome are associated with arrhythmogenic cardiomyopathy (AC; also referred to as "ARVC" or "ARVD… Expand Background: Fibroblast growth factor 14 (FGF14) binds to and regulates the voltage-gated Na+ (Nav) channel. Results: Inhibition… Expand AIMS
The shRNA-mediated loss of expression of the desmosomal protein plakophilin-2 leads to sodium current (I(Na)) dysfunction… Expand Variations in the gene encoding for the major sodium channel (Nav1.5) in the heart, SCN5A, has been shown to cause a number of… Expand Nodes of Ranvier are specialized axonal domains, at which voltage-gated sodium channels cluster. How axons cluster molecules in… Expand The cannabinoid 1 receptor antagonist AM 251 is known to block the inhibitory effects of endocannabinoids and synthetic… Expand The amiloride-sensitive epithelial sodium channel (ENaC) complex is made up of at least three different subunits α, β, and… Expand Procedures are described for the selective removal of the beta 1 or the beta 2 subunits from the detergent-solubilized channel… Expand