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sinefungin

Known as: Adenosyl-Ornithine, (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid, adenosylornithine 
A natural nucleoside related to S-adenosylmethionine that has been isolated from Streptomyces species with antifungal, antiviral and antiparasitic… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (4)

AdenosineAntifungal AgentsAntimalarialsAntiprotozoal Agents
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Sinefungin VA and dehydrosinefungin V, new antitrypanosomal antibiotics produced by Streptomyces sp. K05-0178
Two new nucleotide antibiotics, named sinefungin VA and dehydrosinefungin V, were separated by cation exchange column… 
2006
2006
Substrate-dependent dihydroxylation of substituted cyclopentenes: toward the syntheses of carbocyclic sinefungin and noraristeromycin.
Carbocyclic nucleosides are of considerable interest for the development of new therapeutic agents. A key reaction in the… 
Highly Cited
2003
Highly Cited
2003
Isolation and characterisation of 5′‐fluorodeoxyadenosine synthase, a fluorination enzyme from Streptomyces cattleya
1995
1995
A model for DNA binding and enzyme action derived from crystallographic studies of the TaqI N6-adenine-methyltransferase.
1995
1995
Sinefungin shares AdoMet-uptake system to enter Leishmania donovani promastigotes.
The involvement of a carrier for sinefungin (SF) uptake in Leishmania donovani promastigotes is indicated by saturation kinetics… 
Highly Cited
1992
Highly Cited
1992
Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii.
We have constructed a genetic linkage map for the parasitic protozoan, Toxoplasma gondii, using randomly selected low copy number… 
Highly Cited
1990
Highly Cited
1990
Inhibition of EcoRI DNA methylase with cofactor analogs.
Highly Cited
1990
Highly Cited
1990
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coli.
The turnover of DNA-adenine-methylase of E. coli strongly decreases when the temperature is lowered. This has allowed us to study… 
1985
1985
Differential effect of sinefungin and its analogs on the multiplication of three Leishmania species
Sinefungin and seven analogs were evaluated in vitro for activity against promastigote multiplication of Leishmania donovani, L… 
1984
1984
Photoaffinity labelling of methyltransferase enzymes with S-adenosylmethionine: effects of methyl acceptor substrates.
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