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simendan

Known as: ((4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl)hydrazono)propanedinitrile, Mesoxalonitrile (+/-)-(P-(1,4,5,6-Tetrahydro-4-Methyl-6-Oxo-3-Pyridazinyl)Phenyl)Hydrazone 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (6)

Anti-Arrhythmia AgentsCardiotonic AgentsHydrazonesPhosphodiesterase Inhibitors

Narrower (4)

LevosimendanOR 1259OR-1855dextrosimendan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Enantiomeric analysis of simendan on polysaccharide-based stationary phases by polar organic solvent chromatography.
Herein, the enantiomeric separation of simendan by HPLC with ultraviolet detection method using polysaccharide-based chiral… 
2019
2019
The efficacy of simendan in the treatment of acute heart failure and its impact on NT-proBNP.
OBJECTIVE Simendan is a calcium sensitizer that enhances myocardial contractility but does not affect ventricular diastole… 
2017
2017
The potential of the inodilator levosimendan in maintaining quality of life in advanced heart failure
Abstract Maintaining adequate quality of life (QoL) is an important therapeutic objective for patients with advanced heart… 
Review
2014
Review
2014
Levosimendan in Critical Illness: A Literature Review
Levosimendan, the active enantiomer of simendan, is a calcium sensitizer developed for treatment of decompensated heart failure… 
2004
2004
Enatiomeric analysis of simendan by CE with beta-CD as chiral selector compared with CMPA-HPLC.
The chiral separation of simendan enantiomers using capillary electrophoresis was studied with beta-cyclodextrin (beta-CD) as… 
Highly Cited
2001
Highly Cited
2001
Improved survival with simendan after experimental myocardial infarction in rats.
1996
1996
Enantiomeric bioanalysis of simendan and levosimendan by chiral high-performance liquid chromatography.
rac-Simendan, (+/-)-(R,S)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-phenyl ] hydrazono]propanedinitrile, and the… 
Highly Cited
1994
Highly Cited
1994
Maltooligosaccharides as chiral selectors for the separation of pharmaceuticals by capillary electrophoresis.
Complexation between the linear maltodextrin oligosaccharides and certain enantiomeric compounds of pharmaceutical interest in… 
1994
1994
Pharmacokinetics and pharmacodynamics of simendan, a novel calcium sensitizer, in healthy volunteers
To assess pharmacokinetics and correlation of pharmacokinetics and pharmacodynamics of simendan, a new calcium‐sensitizing… 
1994
1994
Hemodynamic effects of the novel cardiotonic drug simendan: Echocardiographic assessment in healthy volunteers
SummarySimendan is a novel cardiotonic drug with mixed properties, including calcium sensitization. Simendan was given… 
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